[HTML][HTML] Mitochondria and brain disease: a comprehensive review of pathological mechanisms and therapeutic opportunities

VJ Clemente-Suárez, L Redondo-Flórez… - Biomedicines, 2023 - mdpi.com
Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating
apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated …

[HTML][HTML] Mesenchymal stem cell senescence during aging: From mechanisms to rejuvenation strategies

X Jiang, W Li, L Ge, M Lu - Aging and disease, 2023 - ncbi.nlm.nih.gov
In cell transplantation therapy, mesenchymal stem cells (MSCs) are ideal seed cells due to
their easy acquisition and cultivation, strong regenerative capacity, multi-directional …

[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model

AS Cone, X Yuan, L Sun, LC Duke, MP Vreones… - Theranostics, 2021 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that affects more
than 44 million people worldwide. Despite the high disease burden, there is no effective …

Engineering extracellular vesicles by three‐dimensional dynamic culture of human mesenchymal stem cells

X Yuan, L Sun, R Jeske, D Nkosi… - Journal of …, 2022 - Wiley Online Library
Human mesenchymal stem cell (hMSC) derived extracellular vesicles (EVs) have shown
therapeutic potential in recent studies. However, the corresponding therapeutic components …

[HTML][HTML] Upscaling human mesenchymal stromal cell production in a novel vertical-wheel bioreactor enhances extracellular vesicle secretion and cargo profile

R Jeske, C Liu, L Duke, MLC Castro, L Muok, P Arthur… - Bioactive Materials, 2023 - Elsevier
Human mesenchymal stromal cells (hMSCs) are mechanically sensitive undergoing
phenotypic alterations when subjected to shear stress, cell aggregation, and substrate …

Mitochondria pleiotropism in stem cell senescence: Mechanisms and therapeutic approaches

C Mas-Bargues - Free Radical Biology and Medicine, 2023 - Elsevier
Aging is a complex biological process characterized by a progressive decline in cellular and
tissue function, ultimately leading to organismal aging. Stem cells, with their regenerative …

[HTML][HTML] Bioenergetic alterations of metabolic redox coenzymes as NADH, FAD and FMN by means of fluorescence lifetime imaging techniques

S Kalinina, C Freymueller, N Naskar… - International Journal of …, 2021 - mdpi.com
Metabolic FLIM (fluorescence lifetime imaging) is used to image bioenergetic status in cells
and tissue. Whereas an attribution of the fluorescence lifetime of coenzymes as an indicator …

[HTML][HTML] Nicotinamide as a foundation for treating neurodegenerative disease and metabolic disorders

K Maiese - Current neurovascular research, 2021 - ncbi.nlm.nih.gov
Neurodegenerative disorders impact more than one billion individuals worldwide and are
intimately tied to metabolic disease that can affect another nine hundred individuals …

[HTML][HTML] In Vitro Culture Expansion Shifts the Immune Phenotype of Human Adipose-Derived Mesenchymal Stem Cells

R Jeske, X Yuan, Q Fu, BA Bunnell… - Frontiers in …, 2021 - frontiersin.org
Human mesenchymal stem or stromal cells (hMSCs) are known for their potential in
regenerative medicine due to their differentiation abilities, secretion of trophic factors, and …

[HTML][HTML] Innovative therapeutic strategies for cardiovascular disease

K Maiese - EXCLI journal, 2023 - ncbi.nlm.nih.gov
As a significant non-communicable disease, cardiovascular disease is the leading cause of
death for both men and women, comprises almost twenty percent of deaths in most racial …