[HTML][HTML] Mitochondria and brain disease: a comprehensive review of pathological mechanisms and therapeutic opportunities
VJ Clemente-Suárez, L Redondo-Flórez… - Biomedicines, 2023 - mdpi.com
Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating
apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated …
apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated …
[HTML][HTML] Mesenchymal stem cell senescence during aging: From mechanisms to rejuvenation strategies
X Jiang, W Li, L Ge, M Lu - Aging and disease, 2023 - ncbi.nlm.nih.gov
In cell transplantation therapy, mesenchymal stem cells (MSCs) are ideal seed cells due to
their easy acquisition and cultivation, strong regenerative capacity, multi-directional …
their easy acquisition and cultivation, strong regenerative capacity, multi-directional …
[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model
Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that affects more
than 44 million people worldwide. Despite the high disease burden, there is no effective …
than 44 million people worldwide. Despite the high disease burden, there is no effective …
Engineering extracellular vesicles by three‐dimensional dynamic culture of human mesenchymal stem cells
Human mesenchymal stem cell (hMSC) derived extracellular vesicles (EVs) have shown
therapeutic potential in recent studies. However, the corresponding therapeutic components …
therapeutic potential in recent studies. However, the corresponding therapeutic components …
[HTML][HTML] Upscaling human mesenchymal stromal cell production in a novel vertical-wheel bioreactor enhances extracellular vesicle secretion and cargo profile
Human mesenchymal stromal cells (hMSCs) are mechanically sensitive undergoing
phenotypic alterations when subjected to shear stress, cell aggregation, and substrate …
phenotypic alterations when subjected to shear stress, cell aggregation, and substrate …
Mitochondria pleiotropism in stem cell senescence: Mechanisms and therapeutic approaches
C Mas-Bargues - Free Radical Biology and Medicine, 2023 - Elsevier
Aging is a complex biological process characterized by a progressive decline in cellular and
tissue function, ultimately leading to organismal aging. Stem cells, with their regenerative …
tissue function, ultimately leading to organismal aging. Stem cells, with their regenerative …
[HTML][HTML] Bioenergetic alterations of metabolic redox coenzymes as NADH, FAD and FMN by means of fluorescence lifetime imaging techniques
S Kalinina, C Freymueller, N Naskar… - International Journal of …, 2021 - mdpi.com
Metabolic FLIM (fluorescence lifetime imaging) is used to image bioenergetic status in cells
and tissue. Whereas an attribution of the fluorescence lifetime of coenzymes as an indicator …
and tissue. Whereas an attribution of the fluorescence lifetime of coenzymes as an indicator …
[HTML][HTML] Nicotinamide as a foundation for treating neurodegenerative disease and metabolic disorders
K Maiese - Current neurovascular research, 2021 - ncbi.nlm.nih.gov
Neurodegenerative disorders impact more than one billion individuals worldwide and are
intimately tied to metabolic disease that can affect another nine hundred individuals …
intimately tied to metabolic disease that can affect another nine hundred individuals …
[HTML][HTML] In Vitro Culture Expansion Shifts the Immune Phenotype of Human Adipose-Derived Mesenchymal Stem Cells
Human mesenchymal stem or stromal cells (hMSCs) are known for their potential in
regenerative medicine due to their differentiation abilities, secretion of trophic factors, and …
regenerative medicine due to their differentiation abilities, secretion of trophic factors, and …
[HTML][HTML] Innovative therapeutic strategies for cardiovascular disease
K Maiese - EXCLI journal, 2023 - ncbi.nlm.nih.gov
As a significant non-communicable disease, cardiovascular disease is the leading cause of
death for both men and women, comprises almost twenty percent of deaths in most racial …
death for both men and women, comprises almost twenty percent of deaths in most racial …