While cisplatin and carboplatin are active versus most common cancers, epithelial
malignancies are incurable when metastatic. Even if an initial response occurs, acquired …

The MRP family is comprised of nine related ABC transporters that are able to transport
structurally diverse lipophilic anions and function as drug efflux pumps. Investigations of this …

The development of multidrug resistance (MDR) to chemotherapy remains a major
challenge in the treatment of cancer. Resistance exists against every effective anticancer …

Multidrug resistance is a major obstacle to successful cancer treatment. One mechanism by
which cells can become resistant to chemotherapy is the expression of ABC transporters that …

Chemotherapy treatments are considered essential tools to defeat cancer progression and
dissemination to improve patients' quality of life and survival. Although most malignancies …

Drug resistance of tumor cells is recognized as the primary cause of failure of
chemotherapeutic treatment of most human tumors. Although pharmacological factors …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive diseases and is
characterized by high chemoresistance, leading to the lack of effective therapeutic …

ABCG2 was discovered in multi-drug-resistant cancer cells, with the identification of
chemotherapeutic agents, such as mitoxantrone, flavopiridol, methotrexate and irinotecan as …

Chemoresistance and hence the consequent treatment failure is considerably challenging in
clinical cancer therapeutics. The understanding of the genetic variations in chemoresistance …

Multi-drug chemoresistance remains one of the most common reasons for chemotherapy
failure. The membrane transporter protein ABCG2/BCRP1 has been shown in vitro to …