Pancreatic β-cell electrical activity and insulin secretion: of mice and men
P Rorsman, FM Ashcroft - Physiological reviews, 2018 - journals.physiology.org
The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …
L-Type CaV1.2 Calcium Channels: From In Vitro Findings to In Vivo Function
F Hofmann, V Flockerzi, S Kahl… - Physiological …, 2014 - journals.physiology.org
The L-type Cav1. 2 calcium channel is present throughout the animal kingdom and is
essential for some aspects of CNS function, cardiac and smooth muscle contractility …
essential for some aspects of CNS function, cardiac and smooth muscle contractility …
[HTML][HTML] Voltage-gated calcium channels: Novel targets for cancer therapy
Voltage-gated calcium channels (VGCCs) comprise five subtypes: The L‑type; R‑type; N‑
type; P/Q‑type; and T‑type, which are encoded by α1 subunit genes. Calcium ion channels …
type; P/Q‑type; and T‑type, which are encoded by α1 subunit genes. Calcium ion channels …
A circular RNA generated from an intron of the insulin gene controls insulin secretion
L Stoll, A Rodríguez-Trejo, C Guay, F Brozzi… - Nature …, 2020 - nature.com
Fine-tuning of insulin release from pancreatic β-cells is essential to maintain blood glucose
homeostasis. Here, we report that insulin secretion is regulated by a circular RNA containing …
homeostasis. Here, we report that insulin secretion is regulated by a circular RNA containing …
Whole-genome bisulfite sequencing of human pancreatic islets reveals novel differentially methylated regions in type 2 diabetes pathogenesis
Current knowledge about the role of epigenetics in type 2 diabetes (T2D) remains limited.
Only a few studies have investigated DNA methylation of selected candidate genes or a very …
Only a few studies have investigated DNA methylation of selected candidate genes or a very …
Convergent genetic and expression data implicate immunity in Alzheimer's disease
International Genomics of Alzheimer's … - Alzheimer's & …, 2015 - Wiley Online Library
Abstract Background Late‐onset Alzheimer's disease (AD) is heritable with 20 genes
showing genome‐wide association in the International Genomics of Alzheimer's Project …
showing genome‐wide association in the International Genomics of Alzheimer's Project …
Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes
NR Gandasi, P Yin, M Riz… - The Journal of …, 2017 - Am Soc Clin Investig
Loss of first-phase insulin secretion is an early sign of developing type 2 diabetes (T2D).
Ca2+ entry through voltage-gated L-type Ca2+ channels triggers exocytosis of insulin …
Ca2+ entry through voltage-gated L-type Ca2+ channels triggers exocytosis of insulin …
De novo CACAN1D Ca2+ channelopathies: clinical phenotypes and molecular mechanism
NJ Ortner, T Kaserer, JN Copeland… - Pflügers Archiv-European …, 2020 - Springer
The identification of rare disease-causing variants in humans by large-scale next-generation
sequencing (NGS) studies has also provided us with new insights into the …
sequencing (NGS) studies has also provided us with new insights into the …
Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency
Mutations in HNF1A cause Maturity Onset Diabetes of the Young (HNF1A-MODY). To
understand mechanisms of β-cell dysfunction, we generated stem cell-derived pancreatic …
understand mechanisms of β-cell dysfunction, we generated stem cell-derived pancreatic …
ATAC-seq reveals alterations in open chromatin in pancreatic islets from subjects with type 2 diabetes
Impaired insulin secretion from pancreatic islets is a hallmark of type 2 diabetes (T2D).
Altered chromatin structure may contribute to the disease. We therefore studied the impact of …
Altered chromatin structure may contribute to the disease. We therefore studied the impact of …