Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport
SPAK (Ste20-related proline alanine rich kinase) and OSR1 (oxidative stress responsive
kinase) are members of the germinal center kinase VI subfamily of the mammalian Ste20 …
kinase) are members of the germinal center kinase VI subfamily of the mammalian Ste20 …
[HTML][HTML] Regulatory control of the Na–Cl co-transporter NCC and its therapeutic potential for hypertension
Hypertension is the largest risk factor for cardiovascular disease, the leading cause of
mortality worldwide. As blood pressure regulation is influenced by multiple physiological …
mortality worldwide. As blood pressure regulation is influenced by multiple physiological …
A SPAK isoform switch modulates renal salt transport and blood pressure
The renal thick ascending limb (TAL) and distal convoluted tubule (DCT) play central roles in
salt homeostasis and blood pressure regulation. An emerging model suggests that …
salt homeostasis and blood pressure regulation. An emerging model suggests that …
[HTML][HTML] The WNK-SPAK/OSR1 kinases and the cation-chloride cotransporters as therapeutic targets for neurological diseases
In recent years, cation-chloride cotransporters (CCCs) have drawn attention in the medical
neuroscience research. CCCs include the family of Na+-coupled Cl-importers (NCC …
neuroscience research. CCCs include the family of Na+-coupled Cl-importers (NCC …
Deletion of the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant cerebral edema after ischemic stroke
H Zhao, R Nepomuceno, X Gao… - Journal of Cerebral …, 2017 - journals.sagepub.com
The WNK-SPAK kinase signaling pathway controls renal NaCl reabsorption and systemic
blood pressure by regulating ion transporters and channels. A WNK3-SPAK complex is …
blood pressure by regulating ion transporters and channels. A WNK3-SPAK complex is …
Kinase regulation of Na+–K+–2Cl− cotransport in primary afferent neurons
E Delpire, TM Austin - The Journal of physiology, 2010 - Wiley Online Library
The Na+–K+–2Cl− cotransporter NKCC1 is expressed in sensory neurons where it
accumulates intracellular Cl− and facilitates primary afferent depolarization. Depolarization …
accumulates intracellular Cl− and facilitates primary afferent depolarization. Depolarization …
The WNK/SPAK and IRBIT/PP1 pathways in epithelial fluid and electrolyte transport
Fluid and electrolyte homeostasis is a fundamental physiological function required for
survival and is associated with a plethora of diseases when aberrant. Systemic fluid and …
survival and is associated with a plethora of diseases when aberrant. Systemic fluid and …
Gut microbiota-induced microRNA-206-3p increases anxiety-like behaviors by inhibiting expression of Cited2 and STK39
Q Li, J Zhang, Z Gao, Y Zhang, J Gu - Microbial Pathogenesis, 2023 - Elsevier
Background Anxiety disorder is highly prevalent worldwide and represents a chronic and
functionally disabling condition, with high levels of psychological stress characterized by …
functionally disabling condition, with high levels of psychological stress characterized by …
Inhibition of KCC2 in mouse spinal cord neurons leads to hypersensitivity to thermal stimulation
TM Austin, E Delpire - Anesthesia & Analgesia, 2011 - journals.lww.com
BACKGROUND: KCC2, a neuronal-specific K-Cl cotransporter, is involved in pain
perception physiology through its effects on postsynaptic inhibition in spinal cord neurons …
perception physiology through its effects on postsynaptic inhibition in spinal cord neurons …
Effects of SPAK knockout on sensorimotor gating, novelty exploration, and brain area-dependent expressions of NKCC1 and KCC2 in a mouse model of …
SS Yang, CL Huang, HE Chen, CS Tung… - Progress in Neuro …, 2015 - Elsevier
Abstract SPAK (Sterile 20/SPS1-related proline/alanine-rich kinase) is a protein kinase
belonging to the mitogen-activated protein kinase (MAPK) superfamily that has been found …
belonging to the mitogen-activated protein kinase (MAPK) superfamily that has been found …