Engineered EVs designed to target diseases of the CNS
Diseases of the central nervous system (CNS) are challenging to treat, mainly due to the
blood-brain barrier (BBB), which restricts drugs in circulation from entering target regions in …
blood-brain barrier (BBB), which restricts drugs in circulation from entering target regions in …
Exploring the role of polymers to overcome ongoing challenges in the field of extracellular vesicles
Extracellular vesicles (EVs) are naturally occurring nanoparticles released from all
eucaryotic and procaryotic cells. While their role was formerly largely underestimated, EVs …
eucaryotic and procaryotic cells. While their role was formerly largely underestimated, EVs …
Advances of engineered extracellular vesicles-based therapeutics strategy
H Komuro, S Aminova, K Lauro… - Science and Technology …, 2022 - Taylor & Francis
Extracellular vesicles (EVs) are a heterogeneous population of lipid bilayer membrane-
bound vesicles which encapsulate bioactive molecules, such as nucleic acids, proteins, and …
bound vesicles which encapsulate bioactive molecules, such as nucleic acids, proteins, and …
Modification of Extracellular Vesicle surfaces: an Approach for targeted drug delivery
Extracellular vesicles (EVs) are a promising drug delivery vehicle candidate because of their
natural origin and intrinsic function of transporting various molecules between different cells …
natural origin and intrinsic function of transporting various molecules between different cells …
[HTML][HTML] The anticancer effect of PASylated calreticulin-targeting L-ASNase in solid tumor bearing mice with immunogenic cell death-inducing chemotherapy
Abstract L-Asparaginase (L-ASNase), a bacterial enzyme that degrades asparagine, has
been commonly used in combination with several chemical drugs to treat malignant …
been commonly used in combination with several chemical drugs to treat malignant …
Protein-based nanoparticles for therapeutic nucleic acid delivery
To realize the full potential of emerging nucleic acid therapies, there is a need for effective
delivery agents to transport cargo to cells of interest. Protein materials exhibit several unique …
delivery agents to transport cargo to cells of interest. Protein materials exhibit several unique …
Exosomes as new generation vehicles for drug delivery systems
N Dilsiz - Journal of Drug Delivery Science and Technology, 2024 - Elsevier
Exosomes are the smallest subtype of mobile extracellular vesicles (EVs), and round sacs
with a diameter between 30 and 120 nm are released by almost all cell types into the …
with a diameter between 30 and 120 nm are released by almost all cell types into the …
iPSC-derived lung and lung cancer organoid model to evaluate cisplatin encapsulated autologous iPSC-derived mesenchymal stromal cell-isolated extracellular …
C Küstermann, K Narbute, V Movčana… - Stem Cell Research & …, 2024 - Springer
Background Lung cancer remains a leading cause of cancer-related mortality globally.
Although recent therapeutic advancements have provided targeted treatment approaches …
Although recent therapeutic advancements have provided targeted treatment approaches …
[HTML][HTML] Revolutionizing cancer treatment via bioengineered extracellular vesicles: Exploring nanovesicles to fully synthetic solutions
M Shao, J Rodrigues, I Sousa-Oliveira… - Applied Materials …, 2024 - Elsevier
The prevalence of cancer on a global scale has necessitated the development of various
therapeutic approaches. However, the effectiveness and safety of existing methods often …
therapeutic approaches. However, the effectiveness and safety of existing methods often …
Therapeutic application of extracellular vesicular EGFR isoform D as a co-drug to target squamous cell cancers with tyrosine kinase inhibitors
SY Toh, HS Leong, FT Chong, DM Rodrigues-Junior… - Developmental Cell, 2024 - cell.com
Targeting wild-type epidermal growth factor receptor (EGFR) using tyrosine kinase inhibitors
(TKIs) never achieved its purported success in cancers such as head and neck squamous …
(TKIs) never achieved its purported success in cancers such as head and neck squamous …