Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …

Evolution has yielded multiple complex and complementary mechanisms to detect
environmental danger and protect tissues from damage. The nervous system rapidly …

Dendritic cells (DCs) of the cDC2 lineage initiate allergic immunity and in the dermis are
marked by their expression of CD301b. CD301b+ dermal DCs respond to allergens …

Next-generation transcriptomics in combination with imaging-based approaches have
emerged as powerful tools for the characterization of dorsal root ganglion (DRG) neuronal …

Lung nociceptors initiate cough and bronchoconstriction. To elucidate if these fibers also
contribute to allergic airway inflammation, we stimulated lung nociceptors with capsaicin and …

Nutrient stimulation of enteroendocrine L cells induces the release of the incretin and
satiating peptide glucagon-like peptide 1 (GLP-1). The vagus nerve innervates visceral …

The rate of action potential firing in nociceptors is a major determinant of the intensity of
pain. Possible modulators of action potential firing include the HCN ion channels, which …

The somatosensory nervous system is critical for the organism's ability to respond to
mechanical, thermal, and nociceptive stimuli. Somatosensory neurons are functionally and …

Human acute and inflammatory pain requires the expression of voltage-gated sodium
channel Nav1. 7 but its significance for neuropathic pain is unknown. Here we show that …

A vast diversity of salient cues is sensed by numerous classes of primary sensory neurons,
defined by specific neuropeptides, ion channels, or cytoskeletal proteins. Recent evidence …