The actions of many drugs involve enzyme inhibition. This is exemplified by the inhibitors of
monoamine oxidases (MAO) and the cholinsterases (ChE) that have been used for several …

It would not be practical to attempt to deal with all the advances that have informed our
understanding of the behavior and functions of this enzyme over the past 90 years. This …

Transition metal‐catalyzed site‐and stereoselective C− H activation of strained (hetero)
cycloalkanes remains a formidable challenge. We herein report a carbamate‐directed …

Molecular docking is a computational chemistry method which has become essential for the
rational drug design process. In this context, it has had great impact as a successful tool for …

Monoamine oxidase (MAO) inhibitors have made significant contributions and remain an
indispensable approach of molecular and mechanistic diversity for the discovery of …

Copper-catalyzed [3+ 2] cycloadditions of N-tosylcyclopropylamine with alkynes and
alkenes have been accomplished under visible light irradiation. The developed approach is …

Monoamine oxidases (MAOs) catalyse the oxidation of neurotransmitter amines and a wide
variety of primary, secondary and tertiary amine xenobiotics, including therapeutic drugs …

Introduction: Selective monoamine oxidase-B (MAO-B) inhibitors are currently used as
coadjuvants for the treatment of early motor symptoms in Parkinson's disease. They can …

HIGHLIGHTS Compounds that interact with multiple targets but minimally with the
cytochrome P450 system (CYP) address the many factors leading to neurodegeneration …

We report an oxidative ring‐opening strategy to transform acyl, sulfonyl or carbamate
protected aminocyclopropanes into 1, 3‐dielectrophilic carbon intermediates bearing a …