Abstract Carnosine (β-alanyl-l-histidine) was discovered in 1900 as an abundant non-
protein nitrogen-containing compound of meat. The dipeptide is not only found in skeletal …

Extracellular acid can have important effects on neuron function. In central and peripheral
neurons, acid-sensing ion channels (ASICs) have emerged as key receptors for extracellular …

This study characterizes an animal model of persistent mechanical hyperalgesia induced by
repeated intramuscular injections of low pH saline. Saline at pH 4, 5, 6, or 7.2 was injected …

Abstract Carnosine (β-alanyl-l-histidine) is present in high concentrations in human skeletal
muscle. The ingestion of β-alanine, the rate-limiting precursor of carnosine, has been shown …

Solution pH was measured using water proton NMR via chemical exchange dependent
saturation transfer (CEST) with selected chemical exchange sites. Several useful pH …

Carnosine is a dipeptide with a high concentration in mammalian skeletal muscle. It is
synthesized by carnosine synthase from the amino acids L-histidine and β-alanine, of which …

Clinically, chronic pain and hyperalgesia induced by muscle injury are disabling and difficult
to treat. Cellular and molecular mechanisms underlying chronic muscle-induced …

Carnosine and related dipeptides such as anserine are naturally-occurring histidine-
containing compounds. They are found in several tissues most notably in muscle where they …

Tumor pH is physiologically important since it influences a number of processes relevant to
tumorigenesis and therapy. Hence, knowledge of localized pH within tumors would …

The risk of diabetic nephropathy is partially genetically determined. Diabetic nephropathy is
linked to a gene locus on chromosome 18q22. 3-q23. We aimed to identify the causative …