[HTML][HTML] Physiology and pathophysiology of carnosine
Abstract Carnosine (β-alanyl-l-histidine) was discovered in 1900 as an abundant non-
protein nitrogen-containing compound of meat. The dipeptide is not only found in skeletal …
protein nitrogen-containing compound of meat. The dipeptide is not only found in skeletal …
Acid-sensing ion channels: advances, questions and therapeutic opportunities
JA Wemmie, MP Price, MJ Welsh - Trends in neurosciences, 2006 - cell.com
Extracellular acid can have important effects on neuron function. In central and peripheral
neurons, acid-sensing ion channels (ASICs) have emerged as key receptors for extracellular …
neurons, acid-sensing ion channels (ASICs) have emerged as key receptors for extracellular …
Unilateral intramuscular injections of acidic saline produce a bilateral, long‐lasting hyperalgesia
KA Sluka, A Kalra, SA Moore - … & Nerve: Official Journal of the …, 2001 - Wiley Online Library
This study characterizes an animal model of persistent mechanical hyperalgesia induced by
repeated intramuscular injections of low pH saline. Saline at pH 4, 5, 6, or 7.2 was injected …
repeated intramuscular injections of low pH saline. Saline at pH 4, 5, 6, or 7.2 was injected …
[HTML][HTML] β-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters
W Derave, MS Özdemir, RC Harris… - Journal of applied …, 2007 - journals.physiology.org
Abstract Carnosine (β-alanyl-l-histidine) is present in high concentrations in human skeletal
muscle. The ingestion of β-alanine, the rate-limiting precursor of carnosine, has been shown …
muscle. The ingestion of β-alanine, the rate-limiting precursor of carnosine, has been shown …
Determination of pH using water protons and chemical exchange dependent saturation transfer (CEST)
KM Ward, RS Balaban - … in Medicine: An Official Journal of the …, 2000 - Wiley Online Library
Solution pH was measured using water proton NMR via chemical exchange dependent
saturation transfer (CEST) with selected chemical exchange sites. Several useful pH …
saturation transfer (CEST) with selected chemical exchange sites. Several useful pH …
Muscle carnosine metabolism and β-alanine supplementation in relation to exercise and training
W Derave, I Everaert, S Beeckman, A Baguet - Sports medicine, 2010 - Springer
Carnosine is a dipeptide with a high concentration in mammalian skeletal muscle. It is
synthesized by carnosine synthase from the amino acids L-histidine and β-alanine, of which …
synthesized by carnosine synthase from the amino acids L-histidine and β-alanine, of which …
Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1
Clinically, chronic pain and hyperalgesia induced by muscle injury are disabling and difficult
to treat. Cellular and molecular mechanisms underlying chronic muscle-induced …
to treat. Cellular and molecular mechanisms underlying chronic muscle-induced …
Carnosine: its properties, functions and potential therapeutic applications
PJ Quinn, AA Boldyrev, VE Formazuyk - Molecular aspects of Medicine, 1992 - Elsevier
Carnosine and related dipeptides such as anserine are naturally-occurring histidine-
containing compounds. They are found in several tissues most notably in muscle where they …
containing compounds. They are found in several tissues most notably in muscle where they …
In vivo imaging of extracellular pH using 1H MRSI
R Van Sluis, ZM Bhujwalla… - … in Medicine: An …, 1999 - Wiley Online Library
Tumor pH is physiologically important since it influences a number of processes relevant to
tumorigenesis and therapy. Hence, knowledge of localized pH within tumors would …
tumorigenesis and therapy. Hence, knowledge of localized pH within tumors would …
Carnosine as a Protective Factor in Diabetic Nephropathy: Association With a Leucine Repeat of the Carnosinase Gene CNDP1
B Janssen, D Hohenadel, P Brinkkoetter, V Peters… - Diabetes, 2005 - Am Diabetes Assoc
The risk of diabetic nephropathy is partially genetically determined. Diabetic nephropathy is
linked to a gene locus on chromosome 18q22. 3-q23. We aimed to identify the causative …
linked to a gene locus on chromosome 18q22. 3-q23. We aimed to identify the causative …