[HTML][HTML] Staphylococcal superantigens spark host-mediated danger signals

T Krakauer, K Pradhan, BG Stiles - Frontiers in immunology, 2016 - frontiersin.org
Staphylococcal enterotoxin B (SEB) of Staphylococcus aureus, and related superantigenic
toxins produced by myriad microbes, are potent stimulators of the immune system causing a …

Bidirectional binding of invariant chain peptides to an MHC class II molecule

S Günther, A Schlundt, J Sticht… - Proceedings of the …, 2010 - National Acad Sciences
T-cell recognition of peptides bound to MHC class II (MHCII) molecules is a central event in
cell-mediated adaptive immunity. The current paradigm holds that prebound class II …

The development of immunotherapies for non-small cell lung cancer

ML Salgaller - Expert Opinion on Biological Therapy, 2002 - Taylor & Francis
Standard of care for non-small cell lung cancer (NSCLC)(surgery, chemotherapy and
radiation) may enhance patient survival but the enhancement is typically transient and quite …

Cross-linking staphylococcal enterotoxin A bound to major histocompatibility complex class I is required for TNF-α secretion

AD Wright, SK Chapes - Cellular immunology, 1999 - Elsevier
The mechanism of how superantigens function to activate cells has been linked to their
ability to bind and cross-link the major histocompatibility complex class II (MHCII) molecule …

Structural and dynamic properties of MHCII-peptide complexes

A Schlundt - 2012 - refubium.fu-berlin.de
Proteine des Haupthistokompatibilitätskomplexes (MHC) präsentieren peptidische Antigene
gegenüber T-Lymphozyten. Antigene extrazellulärer Herkunft werden dabei durch MHCII …