[HTML][HTML] Engineered M13 phage as a novel therapeutic bionanomaterial for clinical applications: From tissue regeneration to cancer therapy

C Chang, W Guo, X Yu, C Guo, N Zhou, X Guo… - Materials Today Bio, 2023 - Elsevier
Bacteriophages (phages) are nanostructured viruses with highly selective antibacterial
properties that have gained attention beyond eliminating bacteria. Specifically, M13 phages …

Human stem cells for cardiac disease modeling and preclinical and clinical applications—are we on the road to success?

CD Correia, A Ferreira, MT Fernandes, BM Silva… - Cells, 2023 - mdpi.com
Cardiovascular diseases (CVDs) are pointed out by the World Health Organization (WHO)
as the leading cause of death, contributing to a significant and growing global health and …

SERCA2 phosphorylation at serine 663 is a key regulator of Ca2+ homeostasis in heart diseases

F Gonnot, L Boulogne, C Brun, M Dia, Y Gouriou… - Nature …, 2023 - nature.com
Despite advances in cardioprotection, new therapeutic strategies capable of preventing
ischemia-reperfusion injury of patients are still needed. Here, we discover that sarcoplasmic …

The current dilemma and breakthrough of stem cell therapy in ischemic heart disease

C Liu, D Han, P Liang, Y Li, F Cao - Frontiers in Cell and …, 2021 - frontiersin.org
Ischemic heart disease (IHD) is the leading cause of mortality worldwide. Stem cell
transplantation has become a promising approach for the treatment of IHD in recent …

Novel applications of mesenchymal stem cell-derived exosomes for myocardial infarction therapeutics

SJ Ozaki Tan, JF Floriano, L Nicastro, C Emanueli… - Biomolecules, 2020 - mdpi.com
Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity globally,
representing approximately a third of all deaths every year. The greater part of these cases …

Human induced pluripotent stem cell-based platform for modeling cardiac ischemia

M Häkli, J Kreutzer, AJ Mäki, H Välimäki, H Lappi… - Scientific reports, 2021 - nature.com
Ischemic heart disease is a major cause of death worldwide, and the only available therapy
to salvage the tissue is reperfusion, which can initially cause further damage. Many …

Electrophysiological Changes of Human‐Induced Pluripotent Stem Cell‐Derived Cardiomyocytes during Acute Hypoxia and Reoxygenation

M Häkli, J Kreutzer, AJ Mäki, H Välimäki… - Stem cells …, 2022 - Wiley Online Library
Ischemic heart disease is the most common cardiovascular disease and a major burden for
healthcare worldwide. However, its pathophysiology is still not fully understood, and human …

Extracellular vesicles of GMSCs alleviate aging-related cell senescence

HZ Shi, JC Zeng, SH Shi… - Journal of Dental …, 2021 - journals.sagepub.com
Healthy aging is a complex biological process with progressive accumulation of senescent
cells characterized by stable cell cycle arrest, resulting in impaired homeostasis …

Stem cell-derived exosomes potential therapeutic roles in cardiovascular diseases

S Jayaraman, D Gnanasampanthapandian… - Frontiers in …, 2021 - frontiersin.org
Owing to myocardial abnormalities, cardiac ailments are considered to be the major cause
of morbidity and mortality worldwide. According to a recent study, membranous vesicles that …

[HTML][HTML] Bioreactor-based 3D human myocardial ischemia/reperfusion in vitro model: a novel tool to unveil key paracrine factors upon acute myocardial infarction

MJ Sebastião, P Gomes-Alves, I Reis, B Sanchez… - Translational …, 2020 - Elsevier
During acute myocardial infarction (AMI), Ischemia/Reperfusion (I/R) injury causes
cardiomyocyte (CM) death and loss of tissue function, making AMI one of the major causes …