It is well established that estrogens affect neuroplasticity in a number of brain regions. In
particular, estrogens modulate and mediate spine and synapse formation as well as …

Alzheimer's disease (AD) is a chronic, progressive and prevalent neurodegenerative
disease characterized by the loss of higher cognitive functions and an associated loss of …

This article is part of a Special Issue “Estradiol and Cognition”. There are sex differences in
hippocampus-dependent cognition and neurogenesis suggesting that sex hormones are …

Neurogenesis within the adult hippocampus is modulated by endogenous and exogenous
factors. Here, we review the role of sex hormones in the regulation of adult hippocampal …

Much evidence indicates that women have a higher risk of developing Alzheimer's disease
(AD) than do men. The reason for this gender difference is unclear. We hypothesize that …

Abstract The National Institutes of Health (NIH) has required the inclusion of women in
clinical studies since 1993, which has enhanced our understanding of how biological sex …

It has become generally accepted that new neurones are added and integrated mainly in
two areas of the mammalian CNS, the subventricular zone and the subgranular zone (SGZ) …

Transcriptional profiling was performed to survey the global expression patterns of 20
anatomically distinct sites of the human central nervous system (CNS). Forty-five non-CNS …

Post-menopausal women are at a higher risk of developing Alzheimer's disease (AD) than
males. The higher rates of AD in women are associated with the sharp decline in the …

Past research suggested that androgens may play a role in the regulation of adult
neurogenesis within the dentate gyrus. We tested this hypothesis by manipulating androgen …