A review of healthy and fibrotic myocardium microstructure modeling and corresponding intracardiac electrograms

J Sánchez, A Loewe - Frontiers in Physiology, 2022 - frontiersin.org
Computational simulations of cardiac electrophysiology provide detailed information on the
depolarization phenomena at different spatial and temporal scales. With the development of …

Non-invasive and quantitative estimation of left atrial fibrosis based on P waves of the 12-Lead ECG—a large-scale computational study covering anatomical …

C Nagel, G Luongo, L Azzolin, S Schuler… - Journal of Clinical …, 2021 - mdpi.com
The arrhythmogenesis of atrial fibrillation is associated with the presence of fibrotic atrial
tissue. Not only fibrosis but also physiological anatomical variability of the atria and the …

Differences in atrial substrate localization using late gadolinium enhancement-magnetic resonance imaging, electrogram voltage, and conduction velocity: a cohort …

D Nairn, M Eichenlaub, B Mueller-Edenborn… - Europace, 2023 - academic.oup.com
Aims Electro-anatomical voltage, conduction velocity (CV) mapping, and late gadolinium
enhancement (LGE) magnetic resonance imaging (MRI) have been correlated with atrial …

Using Machine Learning to Characterize Atrial Fibrotic Substrate From Intracardiac Signals With a Hybrid in silico and in vivo Dataset

J Sánchez, G Luongo, M Nothstein, LA Unger… - Frontiers in …, 2021 - frontiersin.org
In patients with atrial fibrillation, intracardiac electrogram signal amplitude is known to
decrease with increased structural tissue remodeling, referred to as fibrosis. In addition to …

Characterization of atrial propagation patterns and fibrotic substrate with a modified omnipolar electrogram strategy in multi-electrode arrays

J Riccio, A Alcaine, S Rocher, L Martinez-Mateu… - Frontiers in …, 2021 - frontiersin.org
Introduction: The omnipolar electrogram method was recently proposed to try to generate
orientation-independent electrograms. It estimates the electric field from the bipolar …

Electroanatomical Conduction Characteristics of Pig Myocardial Tissue Derived from High-Density Mapping

TI Wilhelm, T Lewalter, J Fischer, J Reiser… - Journal of Clinical …, 2023 - mdpi.com
Background: Ultra-high-density mapping systems allow more precise measurement of the
heart chambers at corresponding conduction velocities (CVs) and voltage amplitudes (VAs) …

In atrial fibrillation, omnipolar voltage maps more accurately delineate scar than bipolar voltage maps

C Butcher, C Roney, A Wharmby, N Ahluwalia… - Clinical …, 2023 - jacc.org
Background Optimal method for voltage assessment in AF remains unclear. Objectives This
study evaluated different methods for assessing atrial voltage and their accuracy in …

Location of Parasympathetic Innervation Regions From Electrograms to Guide Atrial Fibrillation Ablation Therapy: An in silico Modeling Study

C Celotto, C Sánchez, KA Mountris, P Laguna… - Frontiers in …, 2021 - frontiersin.org
The autonomic nervous system (ANS) plays an essential role in the generation and
maintenance of cardiac arrhythmias. The cardiac ANS can be divided into its extrinsic and …

Left atrial epicardial adipose tissue exacerbates electrical conduction disturbance in normal‐weight patients undergoing pulmonary vein isolation for atrial fibrillation

S Yamada, T Kaneshiro, M Nodera… - Journal of …, 2023 - Wiley Online Library
Introduction Epicardial adipose tissue (EAT) exacerbates both electrical and structural
remodeling in obese atrial fibrillation (AF) patients, but the impacts of EAT on atrial …

Validating left atrial fractionation and low-voltage substrate during atrial fibrillation and sinus rhythm—a high-density mapping study in persistent atrial fibrillation

T Huang, J Chen, B Müller-Edenborn… - Frontiers in …, 2022 - frontiersin.org
Background Low-voltage-substrate (LVS)-guided ablation for persistent atrial fibrillation (AF)
has been described either in sinus rhythm (SR) or AF. Prolonged fractionated potentials …