A review of the biological activities of lactoferrin: Mechanisms and potential applications

R Hong, A Xie, C Jiang, Y Guo, Y Zhang, J Chen… - Food & Function, 2024 - pubs.rsc.org
Lactoferrin, a multifunctional iron-binding protein found in milk and other body fluids,
possesses numerous biological activities. The functional activity of lactoferrin lies not only in …

The Multifaceted Roles of Bovine Lactoferrin: Molecular Structure, Isolation Methods, Analytical Characteristics, and Biological Properties

T Dyrda-Terniuk, P Pomastowski - Journal of Agricultural and …, 2023 - ACS Publications
Bovine lactoferrin (bLF) is widely known as an iron-binding glycoprotein from the transferrin
family. The bLF molecule exhibits a broad spectrum of biological activity, including iron …

Bovine lactoferrin inhibits SARS‐CoV‐2 and SARS‐CoV‐1 by targeting the RdRp complex and alleviates viral infection in the hamster model

S He, H Qin, L Guan, K Liu, B Hong… - Journal of Medical …, 2023 - Wiley Online Library
Breast milk has been found to inhibit coronavirus infection, while the key components and
mechanisms are unknown. We aimed to determine the components that contribute to the …

Bovine lactoferrin induces cell death in human prostate cancer cells

VP Rocha, SPC Campos, CA Barros… - Oxidative Medicine …, 2022 - Wiley Online Library
Bovine lactoferrin (bLf) is a multifunctional protein widely associated with anticancer activity.
Prostate cancer is the second most frequent type of cancer worldwide. This study was aimed …

Lactoferrin alleviates lipopolysaccharide-induced infantile intestinal immune barrier damage by regulating an ELAVL1-related signaling pathway

C Li, X Liu, Z Huang, Y Zhai, H Li, J Wu - International Journal of …, 2022 - mdpi.com
As the most important intestinal mucosal barrier of the main body, the innate immune barrier
in intestinal tract plays especially pivotal roles in the overall health conditions of infants and …

[HTML][HTML] Influenza A–induced cystic fibrosis transmembrane conductance regulator dysfunction increases susceptibility to Streptococcus pneumoniae

EY Earnhardt, JL Tipper, A D'Mello, MY Jian… - JCI insight, 2023 - ncbi.nlm.nih.gov
Influenza A virus (IAV) infection is commonly complicated by secondary bacterial infections
that lead to increased morbidity and mortality. Our recent work demonstrates that IAV …

Inhibition of SARS-CoV-2 Infection in Vero Cells by Bovine Lactoferrin under Different Iron-Saturation States

NS Alves, AS Azevedo, BM Dias, IS Horbach… - Pharmaceuticals, 2023 - mdpi.com
Despite the rapid mass vaccination against COVID-19, the emergence of new SARS-CoV-2
variants of concern, such as omicron, is still a great distress, and new therapeutic options …

N, S-Doped Carbon Dots Prepared by Peanut Protein Isolates and Cysteamine as Highly Sensitive Fluorescent Sensors for Fe2+, Fe3+ and Lactoferrin

X Wang, X Zu, T Wang, Y Zhao, Y Liang, X Wang… - Polymers, 2022 - mdpi.com
Lactoferrin (LF) is an iron-binding glycoprotein with various biological activities that has
been extensively used in food and medical applications. Several methods for detecting LF …

[HTML][HTML] Impact of ultrafiltration on the physicochemical properties of bovine lactoferrin: Insights into molecular mass, surface morphology, and elemental composition

T Dyrda-Terniuk, P Pomastowski - Journal of Dairy Science, 2024 - Elsevier
The large-scale isolation of bovine lactoferrin (bLF) typically involves using large amounts of
concentrated eluents, which might introduce impurities to the final product. Sometimes …

[HTML][HTML] Valpalf®: A New Nutraceutical Formulation Containing Bovine Lactoferrin That Exhibits Potentiated Biological Activity

L Rosa, G Ianiro, A Niro, G Musci, R Paesano… - International Journal of …, 2024 - mdpi.com
As a nutraceutical, bovine lactoferrin (bLf), an iron-binding glycoprotein involved in innate
immunity, is gaining elevated attention for its ability to exert pleiotropic functions and to be …