The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …

To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …

Dopamine receptors are widely distributed within the brain where they play critical
modulator roles on motor functions, motivation and drive, as well as cognition. The …

The circadian timing system governs daily biological rhythms, synchronising physiology and
behaviour to the temporal world. External time cues, including the light‐dark cycle and …

Rhythmic gene expression is found throughout the central nervous system. This harmonized
regulation can be dependent on-and independent of-the master regulator of biological …

Bipolar affective disorder is a common neuropsychiatric disorder. Although its
neurobiological underpinnings are incompletely understood, the dopamine hypothesis has …

The physiological identity of every cell is maintained by highly specific transcriptional
networks that establish a coherent molecular program that is in tune with nutritional …

Circadian rhythms are 24-h rhythms in physiology and behaviour generated by molecular
clocks, which serve to coordinate internal time with the external world. The circadian system …

Neurodegenerative diseases encompass a large group of conditions that are clinically and
pathologically diverse yet are linked by a shared pathology of misfolded proteins. The …

The importance of time is ever prevalent in our world, and disruptions to the normal
light/dark and sleep/wake cycle have now become the norm rather than the exception for a …