A cellular mechanism for cortical associations: an organizing principle for the cerebral cortex

M Larkum - Trends in neurosciences, 2013 - cell.com
A basic feature of intelligent systems such as the cerebral cortex is the ability to freely
associate aspects of perceived experience with an internal representation of the world and …

Comparing the ontogeny, neurobiology, and function of social play in hamsters and rats

MA Cooper, JA Grizzell, CJ Whitten… - … & Biobehavioral Reviews, 2023 - Elsevier
Syrian hamsters show complex social play behavior and provide a valuable animal model
for delineating the neurobiological mechanisms and functions of social play. In this review …

Efficient spike-driven learning with dendritic event-based processing

S Yang, T Gao, J Wang, B Deng, B Lansdell… - Frontiers in …, 2021 - frontiersin.org
A critical challenge in neuromorphic computing is to present computationally efficient
algorithms of learning. When implementing gradient-based learning, error information must …

Towards deep learning with segregated dendrites

J Guerguiev, TP Lillicrap, BA Richards - Elife, 2017 - elifesciences.org
Deep learning has led to significant advances in artificial intelligence, in part, by adopting
strategies motivated by neurophysiology. However, it is unclear whether deep learning …

The thalamus integrates the macrosystems of the brain to facilitate complex, adaptive brain network dynamics

JM Shine - Progress in neurobiology, 2021 - Elsevier
The human brain is a complex, adaptive system comprised of billions of cells with trillions of
connections. The interactions between the elements of the system oppose this seemingly …

Spike-driven multi-scale learning with hybrid mechanisms of spiking dendrites

S Yang, Y Pang, H Wang, T Lei, J Pan, J Wang, Y Jin - Neurocomputing, 2023 - Elsevier
Neural dendrites play a critical role in various cognitive functions, including spatial
navigation, sensory processing, adaptive learning, and perception. The spatial layout, signal …

Unveiling the diversity of thalamocortical neuron subtypes

F Clascá, P Rubio‐Garrido… - European Journal of …, 2012 - Wiley Online Library
Our current understanding of thalamocortical (TC) circuits is largely based on studies
investigating so‐called 'specific'thalamic nuclei, which receive and transmit sensory …

Thalamic input to distal apical dendrites in neocortical layer 1 is massive and highly convergent

P Rubio-Garrido, F Pérez-de-Manzo, C Porrero… - Cerebral …, 2009 - academic.oup.com
Input to apical dendritic tufts is now deemed crucial for associative learning, attention, and
similar “feedback” interactions in the cerebral cortex. Excitatory input to apical tufts in …

A perspective on cortical layering and layer-spanning neuronal elements

ME Larkum, LS Petro, RNS Sachdev… - Frontiers in …, 2018 - frontiersin.org
This review article addresses the function of the layers of the cerebral cortex. We develop
the perspective that cortical layering needs to be understood in terms of its functional …

Pharmacological rescue of cognitive function in a mouse model of chemobrain

LD Nguyen, TT Fischer, BE Ehrlich - Molecular Neurodegeneration, 2021 - Springer
Background After chemotherapy, many cancer survivors suffer from long-lasting cognitive
impairment, colloquially known as “chemobrain.” However, the trajectories of cognitive …