A cellular mechanism for cortical associations: an organizing principle for the cerebral cortex
M Larkum - Trends in neurosciences, 2013 - cell.com
A basic feature of intelligent systems such as the cerebral cortex is the ability to freely
associate aspects of perceived experience with an internal representation of the world and …
associate aspects of perceived experience with an internal representation of the world and …
Comparing the ontogeny, neurobiology, and function of social play in hamsters and rats
Syrian hamsters show complex social play behavior and provide a valuable animal model
for delineating the neurobiological mechanisms and functions of social play. In this review …
for delineating the neurobiological mechanisms and functions of social play. In this review …
Efficient spike-driven learning with dendritic event-based processing
S Yang, T Gao, J Wang, B Deng, B Lansdell… - Frontiers in …, 2021 - frontiersin.org
A critical challenge in neuromorphic computing is to present computationally efficient
algorithms of learning. When implementing gradient-based learning, error information must …
algorithms of learning. When implementing gradient-based learning, error information must …
Towards deep learning with segregated dendrites
Deep learning has led to significant advances in artificial intelligence, in part, by adopting
strategies motivated by neurophysiology. However, it is unclear whether deep learning …
strategies motivated by neurophysiology. However, it is unclear whether deep learning …
The thalamus integrates the macrosystems of the brain to facilitate complex, adaptive brain network dynamics
JM Shine - Progress in neurobiology, 2021 - Elsevier
The human brain is a complex, adaptive system comprised of billions of cells with trillions of
connections. The interactions between the elements of the system oppose this seemingly …
connections. The interactions between the elements of the system oppose this seemingly …
Spike-driven multi-scale learning with hybrid mechanisms of spiking dendrites
Neural dendrites play a critical role in various cognitive functions, including spatial
navigation, sensory processing, adaptive learning, and perception. The spatial layout, signal …
navigation, sensory processing, adaptive learning, and perception. The spatial layout, signal …
Unveiling the diversity of thalamocortical neuron subtypes
F Clascá, P Rubio‐Garrido… - European Journal of …, 2012 - Wiley Online Library
Our current understanding of thalamocortical (TC) circuits is largely based on studies
investigating so‐called 'specific'thalamic nuclei, which receive and transmit sensory …
investigating so‐called 'specific'thalamic nuclei, which receive and transmit sensory …
Thalamic input to distal apical dendrites in neocortical layer 1 is massive and highly convergent
P Rubio-Garrido, F Pérez-de-Manzo, C Porrero… - Cerebral …, 2009 - academic.oup.com
Input to apical dendritic tufts is now deemed crucial for associative learning, attention, and
similar “feedback” interactions in the cerebral cortex. Excitatory input to apical tufts in …
similar “feedback” interactions in the cerebral cortex. Excitatory input to apical tufts in …
A perspective on cortical layering and layer-spanning neuronal elements
ME Larkum, LS Petro, RNS Sachdev… - Frontiers in …, 2018 - frontiersin.org
This review article addresses the function of the layers of the cerebral cortex. We develop
the perspective that cortical layering needs to be understood in terms of its functional …
the perspective that cortical layering needs to be understood in terms of its functional …
Pharmacological rescue of cognitive function in a mouse model of chemobrain
LD Nguyen, TT Fischer, BE Ehrlich - Molecular Neurodegeneration, 2021 - Springer
Background After chemotherapy, many cancer survivors suffer from long-lasting cognitive
impairment, colloquially known as “chemobrain.” However, the trajectories of cognitive …
impairment, colloquially known as “chemobrain.” However, the trajectories of cognitive …