SQSTM1/p62: a potential target for neurodegenerative disease
Neurodegenerative diseases, characterized by a progressive loss of brain function, affect
the lives of millions of individuals worldwide. The complexity of the brain poses a challenge …
the lives of millions of individuals worldwide. The complexity of the brain poses a challenge …
Role of post‐translational modifications in Alzheimer's disease
The global burden of Alzheimer's disease (AD) is growing. Valiant efforts to develop clinical
candidates for treatment have continuously met with failure. Currently available palliative …
candidates for treatment have continuously met with failure. Currently available palliative …
[HTML][HTML] High fat diet induces brain insulin resistance and cognitive impairment in mice
High fat diet-induced obesity is associated with insulin resistance (IR) and other chronic, diet
related illnesses, including dementia. Alzheimer disease is the most common form of …
related illnesses, including dementia. Alzheimer disease is the most common form of …
Neuroprotective effects of chronic resveratrol treatment and exercise training in the 3xTg-AD mouse model of Alzheimer's disease
TL Broderick, S Rasool, R Li, Y Zhang… - International journal of …, 2020 - mdpi.com
To date, there is no cure or effective treatment for Alzheimer's disease (AD), a chronic
neurodegenerative condition that affects memory, language, and behavior. AD is …
neurodegenerative condition that affects memory, language, and behavior. AD is …
Circular RNAs in Alzheimer's disease: A new perspective of diagnostic and therapeutic targets
O Vakili, P Asili, Z Babaei, M Mirahmad… - CNS & Neurological …, 2023 - ingentaconnect.com
Background: Circular RNAs (circRNAs), as covalently closed single-stranded noncoding
RNA molecules, have been recently identified to involve in several biological processes …
RNA molecules, have been recently identified to involve in several biological processes …
Beneficial effect of genistein on diabetes-induced brain damage in the ob/ob mouse model
R Li, XW Ding, T Geetha, L Al-Nakkash… - Drug Design …, 2020 - Taylor & Francis
Purpose Diabetes mellitus (DM)-induced brain damage is characterized by cellular,
molecular and functional changes. The mechanisms include oxidative stress …
molecular and functional changes. The mechanisms include oxidative stress …
CuII Binding Properties of N-Truncated Aβ Peptides: In Search of Biological Function
E Stefaniak, W Bal - Inorganic Chemistry, 2019 - ACS Publications
As life expectancy increases, the number of people affected by progressive and irreversible
dementia, Alzheimer's Disease (AD), is predicted to grow. No drug designs seem to be …
dementia, Alzheimer's Disease (AD), is predicted to grow. No drug designs seem to be …
Regulatory roles of phytochemicals on circular RNAs in cancer and other chronic diseases
S Zhang, F Long, H Lin, X Wang, G Jiang… - Pharmacological …, 2021 - Elsevier
As novel non-coding RNAs (ncRNAs), circular RNAs (circRNAs) play an essential role in the
pathogenesis of many chronic diseases, and the regulation of these functional molecules …
pathogenesis of many chronic diseases, and the regulation of these functional molecules …
Neurotrophin receptors in the pathogenesis, diagnosis and therapy of neurodegenerative diseases
J Meldolesi - Pharmacological Research, 2017 - Elsevier
In the last few years, exciting properties have emerged regarding the activation, signaling,
mechanisms of action, and therapeutic targeting of the two types of neurotrophin receptors …
mechanisms of action, and therapeutic targeting of the two types of neurotrophin receptors …
Extranuclear partners of androgen receptor: at the crossroads of proliferation, migration, and neuritogenesis
In this review, we focus on the role played by the protein partners of ligand‐activated
extranuclear androgen receptor (AR) in the final effects of hormone action, such as …
extranuclear androgen receptor (AR) in the final effects of hormone action, such as …