The receptor tyrosine kinase (RTK) AXL has been intrinsically linked to epithelial–
mesenchymal transition (EMT) and promoting cell survival, anoikis resistance, invasion, and …

Simple Summary The tyrosine kinase receptor Axl is an oncogene that promotes cancer
development by increasing proliferation, survival, invasion, and migration in cancer cells. Axl …

Relative label-free quantification (LFQ) of shotgun proteomics data using precursor (MS1)
signal intensities is one of the most commonly used applications to comprehensively and …

Intratumor heterogeneity is a key factor contributing to therapeutic failure and, hence, cancer
lethality. Heterogeneous tumors show partial therapy responses, allowing for the emergence …

HER2 is a driver in solid tumors, mainly breast, oesophageal and gastric cancer, through
activation of oncogenic signaling pathways such as PI3K or MAPK. HER2 overexpression …

An estimated 15–20% of breast cancers overexpress human epidermal growth factor
receptor 2 (HER2/ERBB2/neu). Two small-molecule tyrosine kinase inhibitors (TKIs) …

Simple Summary Drug resistance is the “Achilles' heel” in current oncology. In this sense,
the clinical management of HER2 breast carcinomas (tumors with overexpression …

The mammalian homologs of the D. melanogaster Grainyhead gene, Grainyhead-like 1–3
(GRHL1, GRHL2 and GRHL3), are transcription factors implicated in wound healing …

HER2-positive breast cancers may lose HER2 expression in recurrences and metastases. In
this work, we studied cell lines derived from two transgenic mammary tumors driven by …

Novel pyrazolopyrimidines displaying high potency and selectivity toward SRC family
kinases have been developed by combining ligand-based design and phenotypic screening …