Role of inflammatory molecules in the Alzheimer's disease progression and diagnosis
E Bagyinszky, V Van Giau, K Shim, K Suk… - Journal of the …, 2017 - Elsevier
Alzheimer's disease (AD) is a complex disorder and the most common form of
neurodegenerative dementia. Several genetic, environmental, and physiological factors …
neurodegenerative dementia. Several genetic, environmental, and physiological factors …
Fibroblast growth factor signalling in the diseased nervous system
L Klimaschewski, P Claus - Molecular Neurobiology, 2021 - Springer
Fibroblast growth factors (FGFs) act as key signalling molecules in brain development,
maintenance, and repair. They influence the intricate relationship between myelinating cells …
maintenance, and repair. They influence the intricate relationship between myelinating cells …
Depletion of microglia and inhibition of exosome synthesis halt tau propagation
Accumulation of pathological tau protein is a major hallmark of Alzheimer's disease. Tau
protein spreads from the entorhinal cortex to the hippocampal region early in the disease …
protein spreads from the entorhinal cortex to the hippocampal region early in the disease …
CD4+ effector T cells accelerate Alzheimer's disease in mice
Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder
characterized by pathological deposition of misfolded self-protein amyloid beta (Aβ) which in …
characterized by pathological deposition of misfolded self-protein amyloid beta (Aβ) which in …
Fibroblast growth factor-2 signaling in neurogenesis and neurodegeneration
ME Woodbury, T Ikezu - Journal of Neuroimmune Pharmacology, 2014 - Springer
Abstract Fibroblast growth factor-2 (FGF2), also known as basic FGF, is a multi-functional
growth factor. One of the 22-member FGF family, it signals through receptor tyrosine kinases …
growth factor. One of the 22-member FGF family, it signals through receptor tyrosine kinases …
Amyloid-β specific regulatory T cells attenuate Alzheimer's disease pathobiology in APP/PS1 mice
Abstract Background Regulatory T cells (Tregs) maintain immune tolerance. While Treg-
mediated neuroprotective activities are now well-accepted, the lack of defined antigen …
mediated neuroprotective activities are now well-accepted, the lack of defined antigen …
Hippocampal delivery of neurotrophic factor-α1/carboxypeptidase E gene prevents neurodegeneration, amyloidosis, memory loss in Alzheimer's Disease male mice
Alzheimer's Disease (AD) is a prevalent neurodegenerative disease characterized by tau
hyperphosphorylation, Aβ1-42 aggregation and cognitive dysfunction. Therapeutic agents …
hyperphosphorylation, Aβ1-42 aggregation and cognitive dysfunction. Therapeutic agents …
Ginsenoside and its therapeutic potential for cognitive impairment
H Feng, M Xue, H Deng, S Cheng, Y Hu, C Zhou - Biomolecules, 2022 - mdpi.com
Cognitive impairment (CI) is one of the major clinical features of many neurodegenerative
diseases. It can be aging-related or even appear in non-central nerve system (CNS) …
diseases. It can be aging-related or even appear in non-central nerve system (CNS) …
Antioxidant gene therapy against neuronal cell death
J Navarro-Yepes, L Zavala-Flores, A Anandhan… - Pharmacology & …, 2014 - Elsevier
Oxidative stress is a common hallmark of neuronal cell death associated with
neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, as well as …
neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, as well as …
Gene therapy approach with an emphasis on growth factors: theoretical and clinical outcomes in neurodegenerative diseases
The etiology of many neurological diseases affecting the central nervous system (CNS) is
unknown and still needs more effective and specific therapeutic approaches. Gene therapy …
unknown and still needs more effective and specific therapeutic approaches. Gene therapy …