Abstract Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate
acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Alterations in DNA damage response (DDR) pathways are hallmarks of cancer. Incorrect
repair of DNA lesions often leads to genomic instability. Ataxia telangiectasia mutated …

Sirtuins are NAD+-dependent deacetylase and deacylase enzymes that control important
cellular processes, including DNA damage repair, cellular metabolism, mitochondrial …

Aging is a chronic yet natural physiological decline of the body. Throughout life, humans are
continuously exposed to a variety of exogenous and endogenous stresses, which engender …

Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function
regulation, play important roles in regulating a variety of cellular physiological and …

In our previous study, we reported that sirtuin5 (SIRT5), a member of the NAD+-dependent
class III histone deacetylase family, is highly expressed in colorectal cancer (CRC). Herein …

Aging is the result of the accumulation of a wide variety of molecular and cellular damage
over time. This has been associated with a number of features termed hallmarks of aging …

Protein acetylation is conserved across phylogeny and has been recognized as one of the
most prominent post-translational modifications since its discovery nearly 60 years ago …

The reversible post-translational modification (PTM) of proteins plays an important role in
many cellular processes. Lysine crotonylation (Kcr) is a newly identified PTM, but its …