Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …

Mitochondrial diseases are clinically heterogeneous disorders caused by a wide spectrum
of mutations in genes encoded by either the nuclear or the mitochondrial genome …

Contrary to the long-held view that most humans harbour only identical mitochondrial
genomes, deep resequencing has uncovered unanticipated extreme genetic variation within …

Mitochondria are subject to unique genetic control by both nuclear DNA and their own
genome, mitochondrial DNA (mtDNA), of which each mitochondrion contains multiple …

Mitochondrial diseases are a group of genetic disorders that are characterized by defects in
oxidative phosphorylation and caused by mutations in genes in the nuclear DNA (nDNA) …

Once considered exclusively the cell's powerhouse, mitochondria are now recognized to
perform multiple essential functions beyond energy production, impacting most areas of cell …

Inherited mitochondrial DNA (mtDNA) diseases were discovered 30 years ago, and their
characterization has provided a new perspective on the etiology of the common metabolic …

Parents' stressful experiences can influence an offspring's vulnerability to many pathological
conditions, including psychopathologies, and their effects may even endure for several …

Mitochondria are dynamic bioenergetic organelles whose maintenance requires around
1500 proteins from two genomes. Mutations in either the mitochondrial or nuclear genome …