Abstract Indoleamine 2, 3-dioxygenase 1 (IDO1) is activated in chronic inflammatory states,
eg, in the aging process and age-related diseases. IDO1 enzyme catabolizes L-tryptophan …

Evidence suggests that various innate immune system components are involved in
pathological inflammatory conditions. Among these components, the NLR family pyrin …

Ulcerative colitis (UC), one of the two main types of inflammatory bowel disease, has no
effective treatment. Rosmarinic acid (RA) is a polyphenol that, when administered orally, is …

Background: NOD-like receptor pyrin domain-3 (NLRP3) inflammasome activation is a
double-edged sword in tumorigenesis. Whether NLRP3 is involved in the progression and …

In an ageing society, neurodegenerative diseases have attracted attention because of their
high incidence worldwide. Despite extensive research, there is a lack of conclusive insights …

A meta-analysis of publicly available transcriptomic datasets was performed to identify
metabolic pathways profoundly implicated in the progression and treatment of inflammatory …

Inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disease that affects
more than 3.5 million people, with rising prevalence. It deeply affects patients' daily life …

The diet represents one environmental risk factor controlling the progression of type 1
diabetes (T1D) in genetically susceptible individuals. Consequently, understanding which …

Background Despite long-standing recognition in the significance of mucus overproduction
in asthma, its etiology remains poorly understood. Muc5ac is a secretory mucin that has …

Ongoing research explores the underlying causes of ulcerative colitis and Crohn's disease.
Many experts suggest that dysbiosis in the gut microbiota and genetic, immunological, and …