Recent advances in low-frequency Raman spectroscopy for pharmaceutical applications

K Bērziņš, SJ Fraser-Miller, KC Gordon - International Journal of …, 2021 - Elsevier
Low-frequency Raman (LFR) spectroscopy probes vibrational modes related to long-range
order (ie, crystallinity) that can provide unique information on the solid-state/structural …

[HTML][HTML] Opportunities for milk and milk-related systems as 'new'low-cost excipient drug delivery materials

M Salim, T Eason, BJ Boyd - Advanced Drug Delivery Reviews, 2022 - Elsevier
Milk is well recognised as an amazing delivery system for essential lipids, poorly soluble
nutrients, sugars, amino acids and delivery of critical biological molecules to sustain the …

In Operando Analysis of Milk-Based Oral Formulations during Digestion Using Synchrotron Small-Angle X-ray Scattering Coupled to Low-Frequency Raman …

K Be̅rziņš, P Meiland, A Aljabbari… - Analytical …, 2024 - ACS Publications
A low-frequency Raman (LFR) probe was coupled to an in-line small-angle X-ray scattering
(SAXS) beamline to test the capabilities of a combinatory approach for the determination of …

The influence of gastrointestinal biomolecules on solid-state transformations in pharmaceutical particulates

A Aljabbari, S Kihara, T Rades, BJ Boyd… - Molecular …, 2023 - ACS Publications
Adsorption of gut relevant biomolecules onto particles after oral administration of solid oral
dosage forms is expected to form a “gastrointestinal corona”, which could influence solution …

[HTML][HTML] Emerging challenges in assessing bio-based nanosystems' behaviour under in vitro digestion focused on food applications–A critical view and future …

D Madalena, JM Fernandes, Z Avelar… - Food Research …, 2022 - Elsevier
The current consumers' demand for high quality food products together with the growing
awareness regarding the link between health and nutrition has led to the development of …

Investigations on the Novel Antimalarial Ferroquine in Biomimetic Solutions Using Deep UV Resonance Raman Spectroscopy and Density Functional Theory

R Domes, T Frosch - Analytical Chemistry, 2023 - ACS Publications
Deep ultraviolet (DUV) resonance Raman experiments are performed, investigating the
novel, promising antimalarial ferroquine (FQ). Two buffered aqueous solutions with pH …

Solving the computational puzzle: Toward a pragmatic pathway for modeling low-energy vibrational modes of pharmaceutical crystals

K Be̅rziņš, JJ Sutton, SJ Fraser-Miller… - Crystal Growth & …, 2020 - ACS Publications
Five pharmaceutically relevant compounds with increasing molecular complexity, benzoic
acid, diphenylacetic acid, l-tyrosine, celecoxib (form III), and carvedilol (form II), were …

Characterization of Variably Substituted Hydroxyapatites Using Low-Frequency Raman Spectroscopy

J Kirkham, TM Korter, K Be̅rziņš… - Crystal Growth & …, 2023 - ACS Publications
Low-frequency Raman spectroscopy was used to characterize variably substituted
hydroxyapatites with Sr2+, F–, and CO32–as the substituting species in the crystalline and …

Application of Low-Frequency Raman Spectroscopy to Probe Dynamics of Lipid Mesophase Transformations upon Hydration

LS Krog, JJK Kirkensgaard, V Fodera… - The Journal of …, 2023 - ACS Publications
Low-frequency Raman (LFR) spectroscopy is presented as a viable tool for studying the
hydration characteristics of lyotropic liquid crystal systems herein. Monoolein was used as a …

Monitoring the isothermal dehydration of crystalline hydrates using low-frequency Raman spectroscopy

C Robert, SJ Fraser-Miller, K Berzins… - Molecular …, 2021 - ACS Publications
Detection of the solid-state forms of pharmaceutical compounds is important from the drug
performance point of view. Low-frequency Raman (LFR) spectroscopy has been …