Vimentin intermediate filaments as potential target for cancer treatment
K Strouhalova, M Přechová, A Gandalovičová… - Cancers, 2020 - mdpi.com
Intermediate filaments constitute the third component of the cellular skeleton. Unlike actin
and microtubule cytoskeletons, the intermediate filaments are composed of a wide variety of …
and microtubule cytoskeletons, the intermediate filaments are composed of a wide variety of …
Vimentin: Regulation and pathogenesis
Vimentin, an abundant cytoplasmic intermediate filament protein, is recognized for its
important role in stabilizing intracellular structure. Vimentin has been recognized for its …
important role in stabilizing intracellular structure. Vimentin has been recognized for its …
Vimentin diversity in health and disease
F Danielsson, MKK Peterson, H Caldeira Araújo… - Cells, 2018 - mdpi.com
Vimentin is a protein that has been linked to a large variety of pathophysiological conditions,
including cataracts, Crohn's disease, rheumatoid arthritis, HIV and cancer. Vimentin has also …
including cataracts, Crohn's disease, rheumatoid arthritis, HIV and cancer. Vimentin has also …
Vimentin as a multifaceted player and potential therapeutic target in viral infections
Vimentin is an intermediate filament protein that plays key roles in integration of cytoskeletal
functions, and therefore in basic cellular processes such as cell division and migration …
functions, and therefore in basic cellular processes such as cell division and migration …
CircNR3C2 promotes HRD1-mediated tumor-suppressive effect via sponging miR-513a-3p in triple-negative breast cancer
Y Fan, J Wang, W Jin, Y Sun, Y Xu, Y Wang, X Liang… - Molecular cancer, 2021 - Springer
Background E3 ubiquitin ligase HRD1 (HMG-CoA reductase degradation protein 1, alias
synoviolin with SYVN1 as the official gene symbol) was found downregulated and acting as …
synoviolin with SYVN1 as the official gene symbol) was found downregulated and acting as …
Vimentin as a potential target for diverse nervous system diseases
KZ Chen, SX Liu, YW Li, T He, J Zhao… - Neural regeneration …, 2023 - journals.lww.com
Vimentin is a major type III intermediate filament protein that plays important roles in several
basic cellular functions including cell migration, proliferation, and division. Although vimentin …
basic cellular functions including cell migration, proliferation, and division. Although vimentin …
Mechanical and non‐mechanical functions of filamentous and non‐filamentous vimentin
Intermediate filaments (IFs) formed by vimentin are less understood than their cytoskeletal
partners, microtubules and F‐actin, but the unique physical properties of IFs, especially their …
partners, microtubules and F‐actin, but the unique physical properties of IFs, especially their …
The role of circulating tumor cells in the metastatic cascade: biology, technical challenges, and clinical relevance
Metastases and cancer recurrence are the main causes of cancer death. Circulating Tumor
Cells (CTCs) and disseminated tumor cells are the drivers of cancer cell dissemination. The …
Cells (CTCs) and disseminated tumor cells are the drivers of cancer cell dissemination. The …
Vimentin: from a cytoskeletal protein to a critical modulator of immune response and a target for infection
J Arrindell, B Desnues - Frontiers in Immunology, 2023 - frontiersin.org
Vimentin is an intermediate filament protein that plays a role in cell processes, including cell
migration, cell shape and plasticity, or organelle anchorage. However, studies from over the …
migration, cell shape and plasticity, or organelle anchorage. However, studies from over the …
Targeting vimentin: A multifaceted approach to combatting cancer metastasis and drug resistance
A Tabatabaee, B Nafari, A Farhang, A Hariri… - Cancer and Metastasis …, 2024 - Springer
This comprehensive review explores vimentin as a pivotal therapeutic target in cancer
treatment, with a primary focus on mitigating metastasis and overcoming drug resistance …
treatment, with a primary focus on mitigating metastasis and overcoming drug resistance …