Vimentin intermediate filaments as potential target for cancer treatment

K Strouhalova, M Přechová, A Gandalovičová… - Cancers, 2020 - mdpi.com
Intermediate filaments constitute the third component of the cellular skeleton. Unlike actin
and microtubule cytoskeletons, the intermediate filaments are composed of a wide variety of …

Vimentin: Regulation and pathogenesis

D Paulin, A Lilienbaum, S Kardjian, O Agbulut, Z Li - Biochimie, 2022 - Elsevier
Vimentin, an abundant cytoplasmic intermediate filament protein, is recognized for its
important role in stabilizing intracellular structure. Vimentin has been recognized for its …

Vimentin diversity in health and disease

F Danielsson, MKK Peterson, H Caldeira Araújo… - Cells, 2018 - mdpi.com
Vimentin is a protein that has been linked to a large variety of pathophysiological conditions,
including cataracts, Crohn's disease, rheumatoid arthritis, HIV and cancer. Vimentin has also …

Vimentin as a multifaceted player and potential therapeutic target in viral infections

I Ramos, K Stamatakis, CL Oeste… - International journal of …, 2020 - mdpi.com
Vimentin is an intermediate filament protein that plays key roles in integration of cytoskeletal
functions, and therefore in basic cellular processes such as cell division and migration …

CircNR3C2 promotes HRD1-mediated tumor-suppressive effect via sponging miR-513a-3p in triple-negative breast cancer

Y Fan, J Wang, W Jin, Y Sun, Y Xu, Y Wang, X Liang… - Molecular cancer, 2021 - Springer
Background E3 ubiquitin ligase HRD1 (HMG-CoA reductase degradation protein 1, alias
synoviolin with SYVN1 as the official gene symbol) was found downregulated and acting as …

Vimentin as a potential target for diverse nervous system diseases

KZ Chen, SX Liu, YW Li, T He, J Zhao… - Neural regeneration …, 2023 - journals.lww.com
Vimentin is a major type III intermediate filament protein that plays important roles in several
basic cellular functions including cell migration, proliferation, and division. Although vimentin …

Mechanical and non‐mechanical functions of filamentous and non‐filamentous vimentin

AE Patteson, A Vahabikashi, RD Goldman… - …, 2020 - Wiley Online Library
Intermediate filaments (IFs) formed by vimentin are less understood than their cytoskeletal
partners, microtubules and F‐actin, but the unique physical properties of IFs, especially their …

The role of circulating tumor cells in the metastatic cascade: biology, technical challenges, and clinical relevance

H Dianat-Moghadam, M Azizi, Z Eslami-S… - Cancers, 2020 - mdpi.com
Metastases and cancer recurrence are the main causes of cancer death. Circulating Tumor
Cells (CTCs) and disseminated tumor cells are the drivers of cancer cell dissemination. The …

Vimentin: from a cytoskeletal protein to a critical modulator of immune response and a target for infection

J Arrindell, B Desnues - Frontiers in Immunology, 2023 - frontiersin.org
Vimentin is an intermediate filament protein that plays a role in cell processes, including cell
migration, cell shape and plasticity, or organelle anchorage. However, studies from over the …

Targeting vimentin: A multifaceted approach to combatting cancer metastasis and drug resistance

A Tabatabaee, B Nafari, A Farhang, A Hariri… - Cancer and Metastasis …, 2024 - Springer
This comprehensive review explores vimentin as a pivotal therapeutic target in cancer
treatment, with a primary focus on mitigating metastasis and overcoming drug resistance …