Despite recent advances in our understanding of the disease, glioblastoma (GB) continues
to have limited treatment options and carries a dismal prognosis for patients. Efforts to stratify …

Ubiquitination/ubiquitylation, one of the most fundamental post-translational modifications,
regulates almost every critical cellular process in eukaryotes. Emerging evidence has shown …

Mutational signatures are imprints of pathophysiological processes arising through
tumorigenesis. We generated isogenic CRISPR–Cas9 knockouts (∆) of 43 genes in human …

Ubiquitination regulates numerous cellular processes by generating a versatile
communication system based on eight structurally and functionally different chains linked …

Hexanucleotide repeat expansions represent the most common genetic cause of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, though the mechanisms …

Precise genome editing requires the resolution of nuclease-induced DNA double strand
breaks (DSBs) via the homology-directed repair (HDR) pathway. In mammals, this is …

Anti‐cancer drugs often increase reactive oxygen species (ROS) and cause DNA damage.
Here, we highlight a new cross talk between chronic oxidative stress and the histone variant …

Abstract Histone deacetylase 6 (HDAC6) mediates DNA damage signaling by regulating the
mismatch repair and nucleotide excision repair pathways. Whether HDAC6 also mediates …

The repair of DNA double‑strand breaks (DSBs) is crucial for the preservation of genomic
integrity and the maintenance of cellular homeostasis. Non‑homologous DNA end joining …

Germline mutations in BRCA1 and BRCA2 (BRCA1/2) genes considerably increase breast
and ovarian cancer risk. Given that tumors with these mutations have elevated genomic …