Neuropeptides are important mediators both within the nervous system and between
neurons and other cell types. Neuropeptides such as substance P, calcitonin gene-related …

Long-lasting memories require specific gene expression programmes that are, in part,
orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in …

Epigenetic mechanisms, which include DNA methylation, a variety of post-translational
modifications of histone proteins (acetylation, phosphorylation, methylation, ubiquitination …

The human gut microbiota alters with the aging process. In the first 2-3 years of life, the gut
microbiota varies extensively in composition and metabolic functions. After this period, the …

The core behavioral symptoms of Autism Spectrum Disorders (ASD) include dysregulation of
social communication and the presence of repetitive behaviors. However, there is no …

Recent findings in epigenetics shed new light on the regulation of gene expression in the
central nervous system (CNS) during stress. The most frequently studied epigenetic …

It has been described that exercise can modulate both inflammatory response and
epigenetic modifications, although the effect of exercise on these parameters during the …

There is extensive evidence that aging is associated with impairments in episodic memory.
Many of these changes have been ascribed to neurobiological alterations to the …

Aging and increased amyloid burden are major risk factors for cognitive diseases such as
Alzheimer's disease (AD). Effective therapies for these diseases are lacking. Here, we …

Over the past 30 years, lysine acetylation of histone and nonhistone proteins has become
established as a key modulator of gene expression regulating numerous aspects of cell …