PPAR control of metabolism and cardiovascular functions
D Montaigne, L Butruille, B Staels - Nature Reviews Cardiology, 2021 - nature.com
Peroxisome proliferator-activated receptor-α (PPARα), PPARδ and PPARγ are transcription
factors that regulate gene expression following ligand activation. PPARα increases cellular …
factors that regulate gene expression following ligand activation. PPARα increases cellular …
miRNA deregulation in cancer cells and the tumor microenvironment
R Rupaimoole, GA Calin, G Lopez-Berestein, AK Sood - Cancer discovery, 2016 - AACR
Abstract miRNAs are a key component of the noncoding RNA family. The underlying
mechanisms involved in the interplay between the tumor microenvironment and cancer cells …
mechanisms involved in the interplay between the tumor microenvironment and cancer cells …
MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs
K Gabisonia, G Prosdocimo, GD Aquaro, L Carlucci… - Nature, 2019 - nature.com
Prompt coronary catheterization and revascularization have markedly improved the
outcomes of myocardial infarction, but have also resulted in a growing number of surviving …
outcomes of myocardial infarction, but have also resulted in a growing number of surviving …
FTO-Dependent N6-Methyladenosine Regulates Cardiac Function During Remodeling and Repair
Background: Despite its functional importance in various fundamental bioprocesses, studies
of N6-methyladenosine (m6A) in the heart are lacking. Here, we show that the FTO (fat mass …
of N6-methyladenosine (m6A) in the heart are lacking. Here, we show that the FTO (fat mass …
Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction
Human heart failure, a leading cause of death worldwide, is a prominent example of a
chronic disease that may result from poor cell renewal. The Hippo signaling pathway is an …
chronic disease that may result from poor cell renewal. The Hippo signaling pathway is an …
Clustered miRNAs and their role in biological functions and diseases
MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …
The ever-expanding role of HIF in tumour and stromal biology
EL LaGory, AJ Giaccia - Nature cell biology, 2016 - nature.com
Low oxygen tension (hypoxia) is a hallmark of cancer that influences cancer cell function,
but is also an important component of the tumour microenvironment as it alters the …
but is also an important component of the tumour microenvironment as it alters the …
Non-coding RNAs: the new central dogma of cancer biology
The central dogma of molecular biology states that the functions of RNA revolve around
protein translation. Until the last decade, most researches were geared towards …
protein translation. Until the last decade, most researches were geared towards …
Long noncoding RNAs and microRNAs in cardiovascular pathophysiology
T Thum, G Condorelli - Circulation research, 2015 - Am Heart Assoc
RNAs not encoding proteins have gained prominence over the last couple of decades as
fundamental regulators of cellular function. Not surprisingly, their dysregulation is …
fundamental regulators of cellular function. Not surprisingly, their dysregulation is …
Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway
YM Song, Y Lee, JW Kim, DS Ham, ES Kang, BS Cha… - Autophagy, 2015 - Taylor & Francis
Metformin activates both PRKA and SIRT1. Furthermore, autophagy is induced by either the
PRKA-MTOR-ULK1 or SIRT1-FOXO signaling pathways. We aimed to elucidate the …
PRKA-MTOR-ULK1 or SIRT1-FOXO signaling pathways. We aimed to elucidate the …