Peroxisome proliferator-activated receptor-α (PPARα), PPARδ and PPARγ are transcription
factors that regulate gene expression following ligand activation. PPARα increases cellular …

Abstract miRNAs are a key component of the noncoding RNA family. The underlying
mechanisms involved in the interplay between the tumor microenvironment and cancer cells …

Prompt coronary catheterization and revascularization have markedly improved the
outcomes of myocardial infarction, but have also resulted in a growing number of surviving …

Background: Despite its functional importance in various fundamental bioprocesses, studies
of N6-methyladenosine (m6A) in the heart are lacking. Here, we show that the FTO (fat mass …

Human heart failure, a leading cause of death worldwide, is a prominent example of a
chronic disease that may result from poor cell renewal. The Hippo signaling pathway is an …

MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …

Low oxygen tension (hypoxia) is a hallmark of cancer that influences cancer cell function,
but is also an important component of the tumour microenvironment as it alters the …

The central dogma of molecular biology states that the functions of RNA revolve around
protein translation. Until the last decade, most researches were geared towards …

RNAs not encoding proteins have gained prominence over the last couple of decades as
fundamental regulators of cellular function. Not surprisingly, their dysregulation is …

Metformin activates both PRKA and SIRT1. Furthermore, autophagy is induced by either the
PRKA-MTOR-ULK1 or SIRT1-FOXO signaling pathways. We aimed to elucidate the …