The rising incidence and persistent dismal 5-year overall survival of pancreatic ductal
adenocarcinoma (PDAC) highlight the need for new effective systemic therapies …

Pancreatic ductal adenocarcinoma (PDAC) is an incurable cancer resistant to traditional
treatments, although a limited number of early-stage patients can undergo radical resection …

The current pathological and molecular classification of pancreatic ductal adenocarcinoma
(PDAC) provides limited guidance for treatment options, especially for immunotherapy …

Pancreatic cancer is a major cause of cancer-associated mortality, with a dismal overall
prognosis that has remained virtually unchanged for many decades. Currently, prevention or …

The five-year survival rate of epithelial ovarian cancer (EOC) is approximately 35–40%
despite maximal treatment efforts, highlighting a need for stratification biomarkers for …

Purpose: Pancreatic ductal adenocarcinoma (PDAC) is associated with an
immunosuppressive milieu that supports immune system evasion and disease progression …

Background The characterisation of desmoplastic reaction (DR) has emerged as a new,
independent prognostic determinant in colorectal cancer. Herein, we report the validation of …

Fibrosis plays an important role in many different pathologies. It results from tissue injury,
chronic inflammation, autoimmune reactions and genetic alterations, and it is characterized …

ABSTRACT PDAC is one of the most heterogeneous cancers with low chemotherapeutic
sensitivity due to a dense stroma, a weak vasculature and significant biological aggressivity …

Collagen is one of the most abundant proteins in animals and a major component of the
extracellular matrix (ECM) in tissues. Besides playing a role as a structural building block of …