Dopamine, immunity, and disease

B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - Elsevier
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Noninvasive theta-burst stimulation of the human striatum enhances striatal activity and motor skill learning

MJ Wessel, E Beanato, T Popa, F Windel… - Nature …, 2023 - nature.com
The stimulation of deep brain structures has thus far only been possible with invasive
methods. Transcranial electrical temporal interference stimulation (tTIS) is a novel …

Wave-like dopamine dynamics as a mechanism for spatiotemporal credit assignment

AA Hamid, MJ Frank, CI Moore - Cell, 2021 - cell.com
Significant evidence supports the view that dopamine shapes learning by encoding reward
prediction errors. However, it is unknown whether striatal targets receive tailored dopamine …

Sex differences in dopamine release regulation in the striatum

JE Zachry, SO Nolan, LJ Brady, SJ Kelly… - …, 2021 - nature.com
The mesolimbic dopamine system—which originates in the ventral tegmental area and
projects to the striatum—has been shown to be involved in the expression of sex-specific …

Subcellular proteomics of dopamine neurons in the mouse brain

BD Hobson, SJ Choi, EV Mosharov, RK Soni, D Sulzer… - Elife, 2022 - elifesciences.org
Dopaminergic neurons modulate neural circuits and behaviors via dopamine (DA) release
from expansive, long range axonal projections. The elaborate cytoarchitecture of these …

Axonal mechanisms mediating γ-aminobutyric acid receptor type A (GABA-A) inhibition of striatal dopamine release

PF Kramer, EL Twedell, JH Shin, R Zhang, ZM Khaliq - Elife, 2020 - elifesciences.org
Axons of dopaminergic neurons innervate the striatum where they contribute to movement
and reinforcement learning. Past work has shown that striatal GABA tonically inhibits …

Restoration and targeting of aberrant neurotransmitters in Parkinson's disease therapeutics

D Yadav, P Kumar - Neurochemistry international, 2022 - Elsevier
Neurotransmitters are considered as a fundamental regulator in the process of neuronal
growth, differentiation and survival. Parkinson's Disease (PD) occurs due to extensive …

Alterations in neurotransmitter co-release in Parkinson's disease

K Barcomb, CP Ford - Experimental neurology, 2023 - Elsevier
Parkinson's disease is a neurological disorder characterized by degeneration of midbrain
dopamine neurons, which results in numerous adaptations in basal ganglia circuits …

Direct dopamine terminal regulation by local striatal microcircuitry

SO Nolan, JE Zachry, AR Johnson… - Journal of …, 2020 - Wiley Online Library
Regulation of axonal dopamine release by local microcircuitry is at the hub of several
biological processes that govern the timing and magnitude of signaling events in reward …

Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum

M Caldwell, V Ayo-Jibunoh, JC Mendoza… - Brain Structure and …, 2023 - Springer
Oligodendrocyte progenitor cells (OPCs) receive synaptic innervation from glutamatergic
and GABAergic axons and can be dynamically regulated by neural activity, resulting in …