[HTML][HTML] Progress in targeting PTEN/PI3K/Akt axis in glioblastoma therapy: Revisiting molecular interactions

M Hashemi, S Etemad, S Rezaei, S Ziaolhagh… - Biomedicine & …, 2023 - Elsevier
Glioblastoma (GBM) is one of the most malignant cancers of central nervous system and due
to its sensitive location, surgical resection has high risk and therefore, chemotherapy and …

TLRs as a promise target along with immune checkpoint against gastric cancer

L Cui, X Wang, D Zhang - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Gastric cancer (GC) is one of the most common cancers in the world, and the incidence of
gastric cancer in Asia appears to increase in recent years. Although there is a lot of …

Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA

Y Tong, QMR Gibaut, W Rouse… - Journal of the …, 2022 - ACS Publications
The interactions between cellular RNAs in MDA-MB-231 triple negative breast cancer cells
and a panel of small molecules appended with a diazirine cross-linking moiety and an …

The disulfide catalyst QSOX1 maintains the colon mucosal barrier by regulating Golgi glycosyltransferases

T Ilani, N Reznik, N Yeshaya, T Feldman, P Vilela… - The EMBO …, 2023 - embopress.org
Mucus is made of enormous mucin glycoproteins that polymerize by disulfide crosslinking in
the Golgi apparatus. QSOX1 is a catalyst of disulfide bond formation localized to the Golgi …

Proteomic analyses of fibroblast-and serum-derived exosomes identify QSOX1 as a marker for non-invasive detection of colorectal cancer

N Ganig, F Baenke, ML Thepkaysone, K Lin, VS Rao… - Cancers, 2021 - mdpi.com
Simple Summary Early diagnosis of colorectal cancer (CRC) is crucial to improve patient
outcomes. The tumour microenvironment immediately adapts to malignant transformations …

Targeted degradation of structured RNAs via ribonuclease-targeting chimeras (RiboTacs)

S Haj-Yahia, A Nandi, RI Benhamou - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction RNA structural motifs can serve as recognition sites for proteins or regulatory
elements. Notably, these specific RNA shapes are directly related to many diseases …

Exposure to an environmentally relevant phthalate mixture during prostate development induces microRNA upregulation and transcriptome modulation in rats

WR Scarano, A Bedrat, LG Alonso-Costa… - Toxicological …, 2019 - academic.oup.com
Environmental exposure to phthalates during intrauterine development might increase
susceptibility to neoplasms in reproductive organs such as the prostate. Although studies …

Molecular Inhibitor of QSOX1 Suppresses Tumor Growth In Vivo

AL Fifield, PD Hanavan, DO Faigel, E Sergienko… - Molecular cancer …, 2020 - AACR
Abstract Quiescin sulfhydryl oxidase 1 (QSOX1) is an enzyme overexpressed by many
different tumor types. QSOX1 catalyzes the formation of disulfide bonds in proteins. Because …

Quiescin sulfhydryl oxidase 1 regulates the proliferation, migration and invasion of human glioblastoma cells via PI3K/Akt pathway

Y Geng, C Xu, Y Wang, L Zhang - OncoTargets and therapy, 2020 - Taylor & Francis
Background Quiescin sulfhydryl oxidase 1 (QSOX1) involves in the formation of disulfide
bonds and participates in the protein folding process. In recent years, accumulating …

[HTML][HTML] Inhibition of fibroblast secreted QSOX1 perturbs extracellular matrix in the tumor microenvironment and decreases tumor growth and metastasis in murine …

T Feldman, I Grossman-Haham, Y Elkis, P Vilela… - Oncotarget, 2020 - ncbi.nlm.nih.gov
Extracellular matrix (ECM) plays an important role in tumor development and dissemination,
but few points of therapeutic intervention targeting ECM of the tumor microenvironment have …