Abstract The IL-6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer,
and such hyperactivation is generally associated with a poor clinical prognosis. In the …

Macrophages are the most abundant and one of the most critical cells of tumor immunity.
They provide a bridge between innate and adaptive immunity through releasing cytokines …

Cancer stem cells (CSCs) virtually present in all tumors albeit in small numbers are primarily
responsible for driving cancer progression, metastasis, drug resistance, and recurrence …

Severe coronavirus disease 2019 (COVID-19) causes an uncontrolled activation of the
innate immune response, resulting in acute respiratory distress syndrome and systemic …

Abstract Interleukin-6 (IL-6) is a proinflammatory cytokine which plays an important role in
several regulatory mechanisms of cancer. Moreover, experimental and clinical studies have …

It is well recognized that the presence of cervical lymph node metastasis is the most
important prognostic factor in oral squamous cell carcinoma (OSCC). In solid epithelial …

There are few tumor cell subpopulations with stem cell characteristics in tumor tissue,
defined as cancer stem cells (CSCs) or cancer stem-like cells (CSLCs), which can …

Interleukin-6 (IL-6) is a highly potent cytokine involved in multiple biological processes. It
was previously reported to play a distinct role in inflammation, autoimmune and psychiatric …

Purpose: Locoregional recurrence is a frequent treatment outcome for patients with
advanced head and neck squamous cell carcinoma (HNSCC). Emerging evidence suggests …

Targeting key regulators of the cancer stem cell phenotype to overcome their critical
influence on tumor growth is a promising new strategy for cancer treatment. Here we present …