Pancreatic β-cells are responsible for the synthesis and exocytosis of insulin in response to
an increase in circulating glucose. Insulin secretion occurs in a pulsatile manner, with …

Impaired glucose tolerance arises out of impaired postprandial insulin secretion and
delayed suppression of glucagon. These defects occur early and independently in the …

Background: The liver has the capacity to regulate glucose metabolism by altering the
insulin clearance rate (ICR). The decreased fasting insulin concentrations and enhanced …

Assessment of insulin secretion is key to diagnose postprandial hyperinsulinemic
hypoglycemia (PHH), an increasingly recognized complication following bariatric surgery …

BACKGROUND Metabolic disorders such as type 2 diabetes have been associated with a
decrease in insulin pulse frequency and amplitude. We hypothesized that the T allele at …

The assessments of insulin sensitivity/resistance and of insulin secretion/beta cell function in
humans are still significant challenges. The interest for these traits stems from their proved …

Abnormal postprandial suppression of glucagon in Type 2 diabetes (T2DM) has been
attributed to impaired insulin secretion. Prior work suggests that insulin and glucagon show …

Objective Pulsatile insulin secretion is impaired in diseases such as type 2 diabetes that are
characterized by insulin resistance. This has led to the suggestion that changes in insulin …

Background Nutrient‐mediated release of cholecystokinin and glucagon‐like peptide‐1
(GLP‐1) regulates gastric emptying (GE) via duodenogastric feedback mechanisms; GLP‐1 …

The characteristics of pulsatile insulin secretion are important determinants of type 2
diabetes pathophysiology, but they are understudied due to the difficulties in measuring …