Thermoresponsive polymers and their biomedical application in tissue engineering–a review
F Doberenz, K Zeng, C Willems, K Zhang… - Journal of Materials …, 2020 - pubs.rsc.org
Thermoresponsive polymers hold great potential in the biomedical field, since they enable
the fabrication of cell sheets, in situ drug delivery and 3D-printing under physiological …
the fabrication of cell sheets, in situ drug delivery and 3D-printing under physiological …
The current state of peptide drug discovery: back to the future?
A Henninot, JC Collins, JM Nuss - Journal of medicinal chemistry, 2018 - ACS Publications
Over the past decade, peptide drug discovery has experienced a revival of interest and
scientific momentum, as the pharmaceutical industry has come to appreciate the role that …
scientific momentum, as the pharmaceutical industry has come to appreciate the role that …
Thermoresponsive polymer nanocarriers for biomedical applications
Polymer nanocarriers allow drug encapsulation leading to fragile molecule protection from
early degradation/metabolization, increased solubility of poorly soluble drugs and improved …
early degradation/metabolization, increased solubility of poorly soluble drugs and improved …
Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies
The formulation and delivery of biopharmaceutical drugs, such as monoclonal antibodies
and recombinant proteins, poses substantial challenges owing to their large size and …
and recombinant proteins, poses substantial challenges owing to their large size and …
Elastin-like polypeptides for biomedical applications
AK Varanko, JC Su, A Chilkoti - Annual review of biomedical …, 2020 - annualreviews.org
Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human
elastin. Their unique properties—including lower critical solution temperature phase …
elastin. Their unique properties—including lower critical solution temperature phase …
Applications of elastin-like polypeptides in drug delivery
SR MacEwan, A Chilkoti - Journal of Controlled Release, 2014 - Elsevier
Elastin-like polypeptides (ELPs) are biopolymers inspired by human elastin. Their lower
critical solution temperature phase transition behavior and biocompatibility make them …
critical solution temperature phase transition behavior and biocompatibility make them …
Half‐life extension of biopharmaceuticals using chemical methods: alternatives to PEGylation
SB van Witteloostuijn, SL Pedersen… - ChemMedChem, 2016 - Wiley Online Library
Peptides and proteins constitute a vast pool of excellent drug candidates. Evolution has
equipped these molecules with superior drug‐like properties such as high specificity and …
equipped these molecules with superior drug‐like properties such as high specificity and …
Half-life extended biotherapeutics
RE Kontermann - Expert opinion on biological therapy, 2016 - Taylor & Francis
Introduction: Many of the biotherapeutics approved or under development suffer from a short
half-life necessitating frequent applications in order to maintain a therapeutic concentration …
half-life necessitating frequent applications in order to maintain a therapeutic concentration …
Protein–polymer conjugation—moving beyond PEGylation
Y Qi, A Chilkoti - Current opinion in chemical biology, 2015 - Elsevier
Highlights•Limitations of conjugating poly (ethylene glycol) to proteins and peptides have
become increasingly apparent.•Various polymers have shown promise as PEG …
become increasingly apparent.•Various polymers have shown promise as PEG …
Elastin-like polypeptides in drug delivery
JC Rodríguez-Cabello, FJ Arias, MA Rodrigo… - Advanced drug delivery …, 2016 - Elsevier
The use of recombinant elastin-like materials, or elastin-like recombinamers (ELRs), in drug-
delivery applications is reviewed in this work. Although ELRs were initially used in similar …
delivery applications is reviewed in this work. Although ELRs were initially used in similar …