Thermoresponsive polymers and their biomedical application in tissue engineering–a review

F Doberenz, K Zeng, C Willems, K Zhang… - Journal of Materials …, 2020 - pubs.rsc.org
Thermoresponsive polymers hold great potential in the biomedical field, since they enable
the fabrication of cell sheets, in situ drug delivery and 3D-printing under physiological …

The current state of peptide drug discovery: back to the future?

A Henninot, JC Collins, JM Nuss - Journal of medicinal chemistry, 2018 - ACS Publications
Over the past decade, peptide drug discovery has experienced a revival of interest and
scientific momentum, as the pharmaceutical industry has come to appreciate the role that …

Thermoresponsive polymer nanocarriers for biomedical applications

A Bordat, T Boissenot, J Nicolas, N Tsapis - Advanced drug delivery …, 2019 - Elsevier
Polymer nanocarriers allow drug encapsulation leading to fragile molecule protection from
early degradation/metabolization, increased solubility of poorly soluble drugs and improved …

Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies

S Mitragotri, PA Burke, R Langer - Nature reviews Drug discovery, 2014 - nature.com
The formulation and delivery of biopharmaceutical drugs, such as monoclonal antibodies
and recombinant proteins, poses substantial challenges owing to their large size and …

Elastin-like polypeptides for biomedical applications

AK Varanko, JC Su, A Chilkoti - Annual review of biomedical …, 2020 - annualreviews.org
Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human
elastin. Their unique properties—including lower critical solution temperature phase …

Applications of elastin-like polypeptides in drug delivery

SR MacEwan, A Chilkoti - Journal of Controlled Release, 2014 - Elsevier
Elastin-like polypeptides (ELPs) are biopolymers inspired by human elastin. Their lower
critical solution temperature phase transition behavior and biocompatibility make them …

Half‐life extension of biopharmaceuticals using chemical methods: alternatives to PEGylation

SB van Witteloostuijn, SL Pedersen… - ChemMedChem, 2016 - Wiley Online Library
Peptides and proteins constitute a vast pool of excellent drug candidates. Evolution has
equipped these molecules with superior drug‐like properties such as high specificity and …

Half-life extended biotherapeutics

RE Kontermann - Expert opinion on biological therapy, 2016 - Taylor & Francis
Introduction: Many of the biotherapeutics approved or under development suffer from a short
half-life necessitating frequent applications in order to maintain a therapeutic concentration …

Protein–polymer conjugation—moving beyond PEGylation

Y Qi, A Chilkoti - Current opinion in chemical biology, 2015 - Elsevier
Highlights•Limitations of conjugating poly (ethylene glycol) to proteins and peptides have
become increasingly apparent.•Various polymers have shown promise as PEG …

Elastin-like polypeptides in drug delivery

JC Rodríguez-Cabello, FJ Arias, MA Rodrigo… - Advanced drug delivery …, 2016 - Elsevier
The use of recombinant elastin-like materials, or elastin-like recombinamers (ELRs), in drug-
delivery applications is reviewed in this work. Although ELRs were initially used in similar …