Epigenetics play a crucial role in gene regulation and cellular processes. Most importantly,
its dysregulation can contribute to the development of tumors. Epigenetic modifications, such …

Dorsal root ganglion (DRG) neurons are the first neurons of the sensory pathway. They are
activated by a variety of sensory stimuli that are then transmitted to the central nervous …

Exploiting bacterial DNA-acting enzymes and expanding their repertoire for genome
engineering have been major technological and conceptual advances in molecular biology …

Genome engineering technologies right from viral vector-mediated to protein-based editing—
which include zinc finger nucleases, TALENs, and CRISPR/Cas systems—have been …

Globally, the livelihoods of over a billion people are affected by changes to marine
ecosystems, both structurally and systematically. Resources and ecosystem services …

Just as the mythical Greek Titan Prometheus created humans and brought them the
technology of fire, the biohackers studied here seek to recreate humanity and bring us …

The COVID-19 pandemic highlighted the importance of RNA-based technologies for the
development of new vaccines. Besides vaccines, a world of RNA-based drugs, including …

The CRISPR/Cas9 system has emerged as a powerful tool for mammalian genome
engineering. In basic and translational intervertebral disc (IVD) research, this technique has …

Epilepsy and migraine are both episodic disorders and share clinical as well as
pathophysiological mechanisms. The prevalence of epilepsy in migraine patients is …

Cpf1-linked base editors broaden the targeting scope of programmable cytidine deaminases
by recognizing thymidine-rich protospacer-adjacent motifs (PAM) without inducing DNA …