Protein tyrosine phosphatases (PTPs) are a family of enzymes essential for numerous
cellular processes, and several PTPs have been validated as therapeutic targets for human …

STriatal-Enriched protein tyrosine Phosphatase (STEP) is a tyrosine phosphatase that has
been implicated in Alzheimer's disease (AD), the most common form of dementia, and many …

Lung cancer is one of the most threatening malignant tumors to human health. Epidermal
growth factor receptor (EGFR)‐targeted therapy is a common and essential means for the …

The effects of brain-derived neurotrophic factor (BDNF) in long-term synaptic potentiation
(LTP) are thought to underlie learning and memory formation and are partly mediated by …

Striatal-enriched tyrosine protein phosphatase (STEP) is expressed mainly in the brain. Its
dysregulation is associated with Alzheimer's and Huntington's diseases, schizophrenia …

This commentary focuses on potential molecular mechanisms related to the dysfunctional
synaptic plasticity that is associated with neurodegenerative disorders such as Alzheimer's …

NMDA receptor signaling is critical for the development of synaptic plasticity, learning, and
memory, and dysregulation of NMDAR signaling is implicated in a number of neurological …

Background: Depressive disorders are among four leading causes of burden among the
most disabling medical illnesses and antidepressant drugs (AD) occupying leading …

Striatal-enriched protein tyrosine phosphatase (STEP) modulates key signaling molecules
involved in synaptic plasticity and neuronal function. It is postulated that STEP opposes the …

Recent results indicate that STriatal-Enriched protein tyrosine Phosphatase (STEP) levels
are regulated by brain-derived neurotrophic factor (BDNF), whose expression changes …