Determinants of the rate of protein sequence evolution
The rate and mechanism of protein sequence evolution have been central questions in
evolutionary biology since the 1960s. Although the rate of protein sequence evolution …
evolutionary biology since the 1960s. Although the rate of protein sequence evolution …
ERK1 and ERK2 map kinases: specific roles or functional redundancy?
R Buscà, J Pouysségur, P Lenormand - Frontiers in cell and …, 2016 - frontiersin.org
The MAP kinase signaling cascade Ras/Raf/MEK/ERK has been involved in a large variety
of cellular and physiological processes that are crucial for life. Many pathological situations …
of cellular and physiological processes that are crucial for life. Many pathological situations …
Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants
Establishing the age of each mutation segregating in contemporary human populations is
important to fully understand our evolutionary history, and will help to facilitate the …
important to fully understand our evolutionary history, and will help to facilitate the …
A benchmark of gene expression tissue-specificity metrics
N Kryuchkova-Mostacci… - Briefings in …, 2017 - academic.oup.com
One of the major properties of genes is their expression pattern. Notably, genes are often
classified as tissue specific or housekeeping. This property is of interest to molecular …
classified as tissue specific or housekeeping. This property is of interest to molecular …
Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution
DA Drummond, CO Wilke - Cell, 2008 - cell.com
Strikingly consistent correlations between rates of coding-sequence evolution and gene
expression levels are apparent across taxa, but the biological causes behind the selective …
expression levels are apparent across taxa, but the biological causes behind the selective …
The 3D architecture of the pepper genome and its relationship to function and evolution
The organization of chromatin into self-interacting domains is universal among eukaryotic
genomes, though how and why they form varies considerably. Here we report a …
genomes, though how and why they form varies considerably. Here we report a …
Evolution of protein-coding genes in Drosophila
Several contributing factors have been implicated in evolutionary rate heterogeneity among
proteins, but their evolutionary mechanisms remain poorly characterized. The recently …
proteins, but their evolutionary mechanisms remain poorly characterized. The recently …
Natural selection on genes that underlie human disease susceptibility
R Blekhman, O Man, L Herrmann, AR Boyko, A Indap… - Current biology, 2008 - cell.com
What evolutionary forces shape genes that contribute to the risk of human disease? Do
similar selective pressures act on alleles that underlie simple versus complex disorders [1 …
similar selective pressures act on alleles that underlie simple versus complex disorders [1 …
Null mutations in human and mouse orthologs frequently result in different phenotypes
One-to-one orthologous genes of relatively closely related species are widely assumed to
have similar functions and cause similar phenotypes when deleted from the genome …
have similar functions and cause similar phenotypes when deleted from the genome …
Protein misinteraction avoidance causes highly expressed proteins to evolve slowly
The tempo and mode of protein evolution have been central questions in biology. Genomic
data have shown a strong influence of the expression level of a protein on its rate of …
data have shown a strong influence of the expression level of a protein on its rate of …