Major advances have occurred in recent years in our understanding of HIV-1 assembly,
release and maturation, as work in this field has been propelled forwards by developments …

The ESCRT proteins are an ancient system that buds membranes and severs membrane
necks from their inner face. Three “classical” functions of the ESCRT s have dominated …

A defining property of retroviruses is their ability to assemble into particles that can leave
producer cells and spread infection to susceptible cells and hosts. Virion morphogenesis …

Enveloped viruses escape infected cells by budding through limiting membranes. In the
decade since the discovery that HIV recruits cellular ESCRT (endosomal sorting complexes …

Mammalian cells are capable of delivering multiple types of membrane capsules
extracellularly. The limiting membrane of late endosomes can fuse with the plasma …

The human protein apolipoprotein B mRNA-editing enzyme–catalytic polypeptide-like-3G
(APOBEC3G), also known as CEM-15, mediates a newly described form of innate resistance …

HIV-1 and other retroviruses exit infected cells by budding from the plasma membrane, a
process requiring membrane fission. The primary late assembly (L) domain in the p6 region …

HIV release requires TSG101, a cellular factor that sorts proteins into vesicles that bud into
multivesicular bodies (MVB). To test whether other proteins involved in MVB biogenesis (the …

▪ Abstract Human immunodeficiency virus (HIV) and other retroviruses acquire their
envelopes and spread infection by budding through the limiting membranes of producer …

Membrane budding is a key step in vesicular transport, multivesicular body biogenesis, and
enveloped virus release. These events range from those that are primarily protein driven …