Pacemaking is a basic physiological process, and the cellular mechanisms involved in this
function have always attracted the keen attention of investigators. The “funny”(I f) current …

The heart automaticity is a fundamental physiological function in higher organisms. The
spontaneous activity is initiated by specialized populations of cardiac cells generating …

The sinoatrial node initiates the heartbeat and controls the rate and rhythm of contraction,
thus serving as the pacemaker of the heart. Despite the crucial role of the sinoatrial node in …

Cardiac pacemaking generation and modulation rely on the coordinated activity of several
processes. Although a wealth of evidence indicates a relevant role of the If (“funny,” or …

Electrocardiogram (ECG) is a non-invasive valuable diagnostic tool that is used in clinics for
investigation and monitoring of heart electrical rhythm/conduction, ischemia/injury of heart …

The sinus node (or sinoatrial node [SAN]), the pacemaker of the heart, is a functionally and
structurally heterogeneous tissue, which consists of a large “head” within the right caval vein …

The sinus node is a collection of highly specialised cells constituting the heart's pacemaker.
The molecular underpinnings of its pacemaking abilities are debated. Using high-resolution …

Over the last decade, mouse models have become a popular instrument for studying cardiac
arrhythmias. This review assesses in which respects a mouse heart is a miniature human …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have a key role in the
control of heart rate and neuronal excitability. Ivabradine is the first compound acting on …

About 50 years ago, pioneering work initiated by Silvio Weidmann and others applied the
Hodgkin-Huxley formalism of membrane excitation to interpret the cardiac electrical activity …