Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Alzheimer's disease: many pathways to neurodegeneration
DA Butterfield, SS Hardas… - Journal of Alzheimer's …, 2010 - content.iospress.com
Abstract Recently, the oxidoreductase, glyceraldehyde-3-phosphate dehydrogenase
(GAPDH), has become a subject of interest as more and more studies reveal a surfeit of …
(GAPDH), has become a subject of interest as more and more studies reveal a surfeit of …
[HTML][HTML] Plant cytoplasmic GAPDH: redox post-translational modifications and moonlighting properties
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a ubiquitous enzyme involved in
glycolysis and shown, particularly in animal cells, to play additional roles in several …
glycolysis and shown, particularly in animal cells, to play additional roles in several …
[HTML][HTML] Deciphering functional roles of protein succinylation and glutarylation using genetic code expansion
Post-translational modifications (PTMs) dynamically regulate cellular processes. Lysine
undergoes a range of acylations, including malonylation, succinylation (SucK) and …
undergoes a range of acylations, including malonylation, succinylation (SucK) and …
[HTML][HTML] Target-selective protein S-nitrosylation by sequence motif recognition
S-nitrosylation is a ubiquitous protein modification emerging as a principal mechanism of
nitric oxide (NO)-mediated signal transduction and cell function. S-nitrosylases can use NO …
nitric oxide (NO)-mediated signal transduction and cell function. S-nitrosylases can use NO …
[HTML][HTML] CARM1 methylates GAPDH to regulate glucose metabolism and is suppressed in liver cancer
XY Zhong, XM Yuan, YY Xu, M Yin, WW Yan, SW Zou… - Cell reports, 2018 - cell.com
Increased aerobic glycolysis is a hallmark of cancer metabolism. How cancer cells
coordinate glucose metabolism with extracellular glucose levels remains largely unknown …
coordinate glucose metabolism with extracellular glucose levels remains largely unknown …
The triangle of death in Alzheimer's disease brain: the aberrant cross-talk among energy metabolism, mammalian target of rapamycin signaling, and protein …
Significance: Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder and
represents one of the most disabling conditions. AD shares many features in common with …
represents one of the most disabling conditions. AD shares many features in common with …
Glycolytic enzyme inhibitors in cancer treatment
Background: The radio-and chemotherapeutics currently used for the treatment of cancer
are widely known to be characterized by a low therapeutic index. An interesting approach to …
are widely known to be characterized by a low therapeutic index. An interesting approach to …
Dengue virus NS1 protein modulates cellular energy metabolism by increasing glyceraldehyde-3-phosphate dehydrogenase activity
Dengue is one of the main public health concerns worldwide. Recent estimates indicate that
over 390 million people are infected annually with the dengue virus (DENV), resulting in …
over 390 million people are infected annually with the dengue virus (DENV), resulting in …
High-resolution structure of human D-glyceraldehyde-3-phosphate dehydrogenase
JL Jenkins, JJ Tanner - Acta Crystallographica Section D …, 2006 - journals.iucr.org
GAPDH (d-glyceraldehyde-3-phosphate dehydrogenase) is a multifunctional protein that is
a target for the design of antitrypanosomatid and anti-apoptosis drugs. Here, the first high …
a target for the design of antitrypanosomatid and anti-apoptosis drugs. Here, the first high …
[HTML][HTML] Discovery of a spirocyclic 3-bromo-4, 5-dihydroisoxazole covalent inhibitor of hGAPDH with antiproliferative activity against pancreatic cancer cells
A Galbiati, S Bova, R Pacchiana, C Borsari… - European Journal of …, 2023 - Elsevier
Abstract Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a key glycolytic enzyme,
plays a crucial role in the energy metabolism of cancer cells and has been proposed as a …
plays a crucial role in the energy metabolism of cancer cells and has been proposed as a …