Mesenchymal stem cells (MSCs) have been identified in many adult tissues. MSCs can
regenerate through cell division or differentiate into adipocytes, osteoblasts and …

Epithelial-mesenchymal transition (EMT) is a fundamental process for embryonic
development during which epithelial cells acquire mesenchymal characteristics, and the …

The predominant way in which conventional chemotherapy kills rapidly proliferating cancer
cells is the induction of DNA damage. However, chemoresistance remains the main obstacle …

Twist1 is a well-known regulator of transcription during embryonic organogenesis in many
species. In humans, Twist1 malfunction was first linked to Saethre-Chotzen syndrome and …

In spite of the current advances and achievements in systems biology and translational
medicinal research, the current strategies for cancer therapy, such as radiotherapy, targeted …

Background Prostate cancer remains one of the deadliest neoplasms in developed
countries. Identification of new molecular markers that predict the onset and progression of …

Previous studies showed that five miRNAs (miR-885-5p, miR-1274, miR-210-3p, miR-224
and miR-1290) were upregulated the most in clear cell renal cell carcinoma (ccRCC). Our …

Epithelial-to-mesenchymal transition (EMT) is a key biological process involved in a
multitude of developmental and pathological events. It is characterized by the progressive …

Splicing factor 3B subunit 4 (SF3B4) plays important functional roles not only in pre-mRNA
splicing, but also in the regulation of transcription, translation, and cell signaling, and its …

Abstract E2F transcription factor 3 (E2F3) is oncogenic in tumorigenesis. Alterations in E2F3
functions correspond with poor prognosis in various cancers, underscoring their status for …