The σ 1 and σ 2 receptors are enigmatic proteins that have attracted attention for decades
due to the chemical diversity and therapeutic potential of their ligands. However, despite …

Sigma (σ) receptors are a class of unique proteins with two subtypes: the sigma-1 (σ1)
receptor which is situated at the mitochondria-associated endoplasmic reticulum (ER) …

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The sigma 2 receptor (σ2R) was described pharmacologically more than three decades ago,
but its molecular identity remained obscure until recently when it was identified as …

The σ1 receptor is a poorly understood membrane protein expressed throughout the human
body. Ligands targeting the σ1 receptor are in clinical trials for treatment of Alzheimer's …

The Transient Receptor Potential Vanilloid 1 (TRPV1) ion channel is expressed in
nociceptors where, when activated by chemical or thermal stimuli, it functions as an …

Abstract The sigma-1 receptor (Sig-1R) is encoded by the SIGMAR1 gene and is a
nonopioid transmembrane receptor located in the mitochondrial-associated endoplasmic …

Sigma1 (also known as sigma-1 receptor, Sig1R, σ1 receptor) is a unique pharmacologically
regulated integral membrane chaperone or scaffolding protein. The majority of publications …

The sigma 1 receptor (σ 1 R) is a structurally unique transmembrane protein that functions
as a molecular chaperone in the endoplasmic reticulum (ER), and has been implicated in …

Abstract Sigma-1 receptor (σ1R) knockout (KO) CD1 mice, generated by homologous
recombination, and separate pharmacological studies in wild type (WT) mice were done to …