The molecular function of σ receptors: past, present, and future
HR Schmidt, AC Kruse - Trends in pharmacological sciences, 2019 - cell.com
The σ 1 and σ 2 receptors are enigmatic proteins that have attracted attention for decades
due to the chemical diversity and therapeutic potential of their ligands. However, despite …
due to the chemical diversity and therapeutic potential of their ligands. However, despite …
The sigma receptors in Alzheimer's disease: New potential targets for diagnosis and therapy
T Wang, H Jia - International Journal of Molecular Sciences, 2023 - mdpi.com
Sigma (σ) receptors are a class of unique proteins with two subtypes: the sigma-1 (σ1)
receptor which is situated at the mitochondria-associated endoplasmic reticulum (ER) …
receptor which is situated at the mitochondria-associated endoplasmic reticulum (ER) …
[图书][B] Fanaroff and Martin's neonatal-perinatal medicine e-book: diseases of the fetus and infant
RJ Martin, AA Fanaroff, MC Walsh - 2014 - books.google.com
Tackle your toughest challenges and improve the quality of life and long-term outcomes of
your patients with authoritative guidance from Fanaroff and Martin s Neonatal-Perinatal …
your patients with authoritative guidance from Fanaroff and Martin s Neonatal-Perinatal …
Highly specific σ2R/TMEM97 ligand FEM-1689 alleviates neuropathic pain and inhibits the integrated stress response
MS Yousuf, JJ Sahn, H Yang… - Proceedings of the …, 2023 - National Acad Sciences
The sigma 2 receptor (σ2R) was described pharmacologically more than three decades ago,
but its molecular identity remained obscure until recently when it was identified as …
but its molecular identity remained obscure until recently when it was identified as …
Structural basis for σ1 receptor ligand recognition
The σ1 receptor is a poorly understood membrane protein expressed throughout the human
body. Ligands targeting the σ1 receptor are in clinical trials for treatment of Alzheimer's …
body. Ligands targeting the σ1 receptor are in clinical trials for treatment of Alzheimer's …
TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain
M Ortíz-Rentería, R Juárez-Contreras… - Proceedings of the …, 2018 - National Acad Sciences
The Transient Receptor Potential Vanilloid 1 (TRPV1) ion channel is expressed in
nociceptors where, when activated by chemical or thermal stimuli, it functions as an …
nociceptors where, when activated by chemical or thermal stimuli, it functions as an …
Emerging benefits: pathophysiological functions and target drugs of the sigma-1 receptor in neurodegenerative diseases
N Wu, Y Ye, B Wan, Y Yu, C Liu, Q Chen - Molecular Neurobiology, 2021 - Springer
Abstract The sigma-1 receptor (Sig-1R) is encoded by the SIGMAR1 gene and is a
nonopioid transmembrane receptor located in the mitochondrial-associated endoplasmic …
nonopioid transmembrane receptor located in the mitochondrial-associated endoplasmic …
Sigma1 pharmacology in the context of cancer
FJ Kim, CM Maher - Sigma Proteins: Evolution of the Concept of Sigma …, 2017 - Springer
Sigma1 (also known as sigma-1 receptor, Sig1R, σ1 receptor) is a unique pharmacologically
regulated integral membrane chaperone or scaffolding protein. The majority of publications …
regulated integral membrane chaperone or scaffolding protein. The majority of publications …
Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays
The sigma 1 receptor (σ 1 R) is a structurally unique transmembrane protein that functions
as a molecular chaperone in the endoplasmic reticulum (ER), and has been implicated in …
as a molecular chaperone in the endoplasmic reticulum (ER), and has been implicated in …
Critical role of sigma-1 receptors in central neuropathic pain-related behaviours after mild spinal cord injury in mice
S Castany, G Gris, JM Vela, E Verdú… - Scientific reports, 2018 - nature.com
Abstract Sigma-1 receptor (σ1R) knockout (KO) CD1 mice, generated by homologous
recombination, and separate pharmacological studies in wild type (WT) mice were done to …
recombination, and separate pharmacological studies in wild type (WT) mice were done to …