Spermatogenesis is a complex differentiation process coordinated spatiotemporally across
and along seminiferous tubules. Cellular heterogeneity has made it challenging to obtain …

Mammalian spermatogenesis contains three continuous and organized processes, by which
spermatogonia undergo mitosis and differentiate to spermatocytes, follow on meiosis to form …

A systematic interrogation of male germ cells is key to complete understanding of molecular
mechanisms governing spermatogenesis and the development of new strategies for …

Mammalian gametogenesis involves dramatic and tightly regulated chromatin remodeling,
whose regulatory pathways remain largely unexplored. Here, we generate a comprehensive …

Spermatogenesis is a dynamic developmental process that includes stem cell proliferation
and differentiation, meiotic cell divisions and extreme chromatin condensation. Although …

The multiple morphological abnormalities of the flagella (MMAF) phenotype is among the
most severe forms of sperm defects responsible for male infertility. The phenotype is …

To fully exploit the potential of single-cell functional genomics in the study of development
and disease, robust methods are needed to simplify the analysis of data across samples …

During meiotic prophase I, spermatocytes must balance transcriptional activation with
homologous recombination and chromosome synapsis, biological processes requiring …

Background The development of a safe, effective, reversible, non-hormonal contraceptive
method for men has been an ongoing effort for the past few decades. However, despite …

During spermatogenesis, germ cells undergo massive cellular reconstruction and dynamic
chromatin remodeling to facilitate highly diverse transcriptomes, which are required for the …