Store-operated calcium channels
M Prakriya, RS Lewis - Physiological reviews, 2015 - journals.physiology.org
Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …
virtually all metozoan cells and serve a wide variety of functions ranging from gene …
Diseases caused by mutations in ORAI1 and STIM1
Ca2+ release‐activated Ca2+ (CRAC) channels mediate a specific form of Ca2+ influx
called store‐operated Ca2+ entry (SOCE) that contributes to the function of many cell types …
called store‐operated Ca2+ entry (SOCE) that contributes to the function of many cell types …
Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death
Mixed lineage kinase domain-like protein (MLKL) was identified to function downstream of
receptor interacting protein 3 (RIP3) in tumor necrosis factor-α (TNF)-induced necrosis (also …
receptor interacting protein 3 (RIP3) in tumor necrosis factor-α (TNF)-induced necrosis (also …
Crystal structure of the calcium release–activated calcium channel Orai
X Hou, L Pedi, MM Diver, SB Long - Science, 2012 - science.org
The plasma membrane protein Orai forms the pore of the calcium release–activated calcium
(CRAC) channel and generates sustained cytosolic calcium signals when triggered by …
(CRAC) channel and generates sustained cytosolic calcium signals when triggered by …
Rational design of true monomeric and bright photoactivatable fluorescent proteins
Monomeric (m) Eos2 is an engineered photoactivatable fluorescent protein widely used for
super-resolution microscopy. We show that mEos2 forms oligomers at high concentrations …
super-resolution microscopy. We show that mEos2 forms oligomers at high concentrations …
STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1
Store-operated Ca 2+ channels activated by the depletion of Ca 2+ from the endoplasmic
reticulum (ER) are a major Ca 2+ entry pathway in nonexcitable cells and are essential for T …
reticulum (ER) are a major Ca 2+ entry pathway in nonexcitable cells and are essential for T …
The functional network of ion channels in T lymphocytes
MD Cahalan, KG Chandy - Immunological reviews, 2009 - Wiley Online Library
For more than 25 years, it has been widely appreciated that Ca2+ influx is essential to
trigger T‐lymphocyte activation. Patch clamp analysis, molecular identification, and …
trigger T‐lymphocyte activation. Patch clamp analysis, molecular identification, and …
Molecular basis of calcium signaling in lymphocytes: STIM and ORAI
Ca2+ entry into cells of the peripheral immune system occurs through highly Ca2+-selective
channels known as CRAC (calcium release-activated calcium) channels. CRAC channels …
channels known as CRAC (calcium release-activated calcium) channels. CRAC channels …
SOAR and the polybasic STIM1 domains gate and regulate Orai channels
Influx of Ca2+ through store-operated Ca2+ channels (SOCs) is a central component of
receptor-evoked Ca2+ signals. Orai channels are SOCs,, that are gated by STIM1, a Ca2+ …
receptor-evoked Ca2+ signals. Orai channels are SOCs,, that are gated by STIM1, a Ca2+ …
Calcium signaling in immune cells
M Vig, JP Kinet - Nature immunology, 2009 - nature.com
Calcium acts as a second messenger in many cell types, including lymphocytes. Resting
lymphocytes maintain a low concentration of Ca2+. However, engagement of antigen …
lymphocytes maintain a low concentration of Ca2+. However, engagement of antigen …