Store-operated calcium channels

M Prakriya, RS Lewis - Physiological reviews, 2015 - journals.physiology.org
Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

Diseases caused by mutations in ORAI1 and STIM1

RS Lacruz, S Feske - Annals of the New York Academy of …, 2015 - Wiley Online Library
Ca2+ release‐activated Ca2+ (CRAC) channels mediate a specific form of Ca2+ influx
called store‐operated Ca2+ entry (SOCE) that contributes to the function of many cell types …

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

X Chen, W Li, J Ren, D Huang, W He, Y Song, C Yang… - Cell research, 2014 - nature.com
Mixed lineage kinase domain-like protein (MLKL) was identified to function downstream of
receptor interacting protein 3 (RIP3) in tumor necrosis factor-α (TNF)-induced necrosis (also …

Crystal structure of the calcium release–activated calcium channel Orai

X Hou, L Pedi, MM Diver, SB Long - Science, 2012 - science.org
The plasma membrane protein Orai forms the pore of the calcium release–activated calcium
(CRAC) channel and generates sustained cytosolic calcium signals when triggered by …

Rational design of true monomeric and bright photoactivatable fluorescent proteins

M Zhang, H Chang, Y Zhang, J Yu, L Wu, W Ji… - Nature …, 2012 - nature.com
Monomeric (m) Eos2 is an engineered photoactivatable fluorescent protein widely used for
super-resolution microscopy. We show that mEos2 forms oligomers at high concentrations …

STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1

CY Park, PJ Hoover, FM Mullins, P Bachhawat… - Cell, 2009 - cell.com
Store-operated Ca 2+ channels activated by the depletion of Ca 2+ from the endoplasmic
reticulum (ER) are a major Ca 2+ entry pathway in nonexcitable cells and are essential for T …

The functional network of ion channels in T lymphocytes

MD Cahalan, KG Chandy - Immunological reviews, 2009 - Wiley Online Library
For more than 25 years, it has been widely appreciated that Ca2+ influx is essential to
trigger T‐lymphocyte activation. Patch clamp analysis, molecular identification, and …

Molecular basis of calcium signaling in lymphocytes: STIM and ORAI

PG Hogan, RS Lewis, A Rao - Annual review of immunology, 2009 - annualreviews.org
Ca2+ entry into cells of the peripheral immune system occurs through highly Ca2+-selective
channels known as CRAC (calcium release-activated calcium) channels. CRAC channels …

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

JP Yuan, W Zeng, MR Dorwart, YJ Choi, PF Worley… - Nature cell …, 2009 - nature.com
Influx of Ca2+ through store-operated Ca2+ channels (SOCs) is a central component of
receptor-evoked Ca2+ signals. Orai channels are SOCs,, that are gated by STIM1, a Ca2+ …

Calcium signaling in immune cells

M Vig, JP Kinet - Nature immunology, 2009 - nature.com
Calcium acts as a second messenger in many cell types, including lymphocytes. Resting
lymphocytes maintain a low concentration of Ca2+. However, engagement of antigen …