Iron and leukemia: new insights for future treatments

F Wang, H Lv, B Zhao, L Zhou, S Wang, J Luo… - Journal of Experimental …, 2019 - Springer
Iron, an indispensable element for life, is involved in all kinds of important physiological
activities. Iron promotes cell growth and proliferation, but it also causes oxidative stress …

The clinical significance of iron overload and iron metabolism in myelodysplastic syndrome and acute myeloid leukemia

S Weber, A Parmon, N Kurrle, F Schnütgen… - Frontiers in …, 2021 - frontiersin.org
Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are clonal
hematopoietic stem cell diseases leading to an insufficient formation of functional blood …

Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1α-PPARγ pathway

CC Song, K Pantopoulos, GH Chen, CC Zhong… - Cellular and Molecular …, 2022 - Springer
Iron is an essential micro-element, involved in multiple biological activities in vertebrates.
Excess iron accumulation has been identified as an important mediator of lipid deposition …

Protein carbonylation and lipid peroxidation in hematological malignancies

A Rodríguez-García, R García-Vicente, ML Morales… - Antioxidants, 2020 - mdpi.com
Among the different mechanisms involved in oxidative stress, protein carbonylation and lipid
peroxidation are both important modifications associated with the pathogenesis of several …

From iron chelation to overload as a therapeutic strategy to induce ferroptosis in leukemic cells

E Grignano, R Birsen, N Chapuis, D Bouscary - Frontiers in Oncology, 2020 - frontiersin.org
Despite its crucial importance in numerous physiological processes, iron also causes
oxidative stress and damage which can promote the growth and proliferation of leukemic …

Iron overload-induced oxidative stress in myelodysplastic syndromes and its cellular sequelae

CH Kim, HA Leitch - Critical Reviews in Oncology/Hematology, 2021 - Elsevier
The myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders. MDS
patients often require red blood cell transfusions, resulting in iron overload (IOL). IOL …

Nandrolone induces a stem cell-like phenotype in human hepatocarcinoma-derived cell line inhibiting mitochondrial respiratory activity

F Agriesti, T Tataranni, C Pacelli, R Scrima… - Scientific Reports, 2020 - nature.com
Nandrolone is a testosterone analogue with anabolic properties commonly abused
worldwide, recently utilized also as therapeutic agent in chronic diseases, cancer included …

The role of iron in benign and malignant hematopoiesis

S Sinha, J Pereira-Reis, A Guerra… - Antioxidants & Redox …, 2021 - liebertpub.com
Significance: Iron is an essential element required for sustaining a normal healthy life.
However, an excess amount of iron in the bloodstream and tissue generates toxic hydroxyl …

Hematologic improvement with iron chelation therapy in myelodysplastic syndromes: Clinical data, potential mechanisms, and outstanding questions

HA Leitch, N Gattermann - Critical Reviews in Oncology/Hematology, 2019 - Elsevier
Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders
characterized by cytopenias and progression to acute myeloid leukemia (AML). Although …

A review of select minerals influencing the haematopoietic process

DC Oliveira, A Nogueira-Pedro, EW Santos… - Nutrition research …, 2018 - cambridge.org
Micronutrients are indispensable for adequate metabolism, such as biochemical function
and cell production. The production of blood cells is named haematopoiesis and this …