Iron and leukemia: new insights for future treatments
F Wang, H Lv, B Zhao, L Zhou, S Wang, J Luo… - Journal of Experimental …, 2019 - Springer
Iron, an indispensable element for life, is involved in all kinds of important physiological
activities. Iron promotes cell growth and proliferation, but it also causes oxidative stress …
activities. Iron promotes cell growth and proliferation, but it also causes oxidative stress …
The clinical significance of iron overload and iron metabolism in myelodysplastic syndrome and acute myeloid leukemia
S Weber, A Parmon, N Kurrle, F Schnütgen… - Frontiers in …, 2021 - frontiersin.org
Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are clonal
hematopoietic stem cell diseases leading to an insufficient formation of functional blood …
hematopoietic stem cell diseases leading to an insufficient formation of functional blood …
Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1α-PPARγ pathway
CC Song, K Pantopoulos, GH Chen, CC Zhong… - Cellular and Molecular …, 2022 - Springer
Iron is an essential micro-element, involved in multiple biological activities in vertebrates.
Excess iron accumulation has been identified as an important mediator of lipid deposition …
Excess iron accumulation has been identified as an important mediator of lipid deposition …
Protein carbonylation and lipid peroxidation in hematological malignancies
Among the different mechanisms involved in oxidative stress, protein carbonylation and lipid
peroxidation are both important modifications associated with the pathogenesis of several …
peroxidation are both important modifications associated with the pathogenesis of several …
From iron chelation to overload as a therapeutic strategy to induce ferroptosis in leukemic cells
E Grignano, R Birsen, N Chapuis, D Bouscary - Frontiers in Oncology, 2020 - frontiersin.org
Despite its crucial importance in numerous physiological processes, iron also causes
oxidative stress and damage which can promote the growth and proliferation of leukemic …
oxidative stress and damage which can promote the growth and proliferation of leukemic …
Iron overload-induced oxidative stress in myelodysplastic syndromes and its cellular sequelae
CH Kim, HA Leitch - Critical Reviews in Oncology/Hematology, 2021 - Elsevier
The myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders. MDS
patients often require red blood cell transfusions, resulting in iron overload (IOL). IOL …
patients often require red blood cell transfusions, resulting in iron overload (IOL). IOL …
Nandrolone induces a stem cell-like phenotype in human hepatocarcinoma-derived cell line inhibiting mitochondrial respiratory activity
F Agriesti, T Tataranni, C Pacelli, R Scrima… - Scientific Reports, 2020 - nature.com
Nandrolone is a testosterone analogue with anabolic properties commonly abused
worldwide, recently utilized also as therapeutic agent in chronic diseases, cancer included …
worldwide, recently utilized also as therapeutic agent in chronic diseases, cancer included …
The role of iron in benign and malignant hematopoiesis
Significance: Iron is an essential element required for sustaining a normal healthy life.
However, an excess amount of iron in the bloodstream and tissue generates toxic hydroxyl …
However, an excess amount of iron in the bloodstream and tissue generates toxic hydroxyl …
Hematologic improvement with iron chelation therapy in myelodysplastic syndromes: Clinical data, potential mechanisms, and outstanding questions
HA Leitch, N Gattermann - Critical Reviews in Oncology/Hematology, 2019 - Elsevier
Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders
characterized by cytopenias and progression to acute myeloid leukemia (AML). Although …
characterized by cytopenias and progression to acute myeloid leukemia (AML). Although …
A review of select minerals influencing the haematopoietic process
DC Oliveira, A Nogueira-Pedro, EW Santos… - Nutrition research …, 2018 - cambridge.org
Micronutrients are indispensable for adequate metabolism, such as biochemical function
and cell production. The production of blood cells is named haematopoiesis and this …
and cell production. The production of blood cells is named haematopoiesis and this …