A biosensor is an analytical device that can be used for detecting analytes and combines a
biological component with a physicochemical detecting transducer. In recent years …

G-protein-coupled receptors (GPCRs) mediate many important physiological functions and
are considered as one of the most successful therapeutic targets for a broad spectrum of …

It is useful to consider seven transmembrane receptors (7TMRs) as disordered proteins able
to allosterically respond to a number of binding partners. Considering 7TMRs as allosteric …

Crucial as molecular sensors for many vital physiological processes, seven-transmembrane
domain G protein-coupled receptors (GPCRs) comprise the largest family of proteins …

It has been estimated that over a billion dollars in resources can be consumed to obtain
clinical approval, and only a few new chemical entities are approved by the US Food and …

A new class of instruments offers an unprecedented combination of label-free detection with
exquisite sensitivity to live-cell responses. These instruments can quantify G-protein-coupled …

Cell‐based assays are an important part of the drug discovery process allowing for
interrogation of targets and pathways in a more physiological setting compared to …

Replacement of the lost myelin sheath is a therapeutic goal for treating demyelinating
diseases of the central nervous system (CNS), such as multiple sclerosis (MS). The G …

As technology advances to the point at which various behaviours of seven-transmembrane
(7TM) receptors (also known as G protein-coupled receptors (GPCRs)) can be observed …

The Gi/o-coupled histamine H4 receptor is highly expressed in hemopoietic cells and is a
promising new target for the treatment of chronic inflammatory diseases. 1-[(5-Chloro-1 H …