Uric acid (UA) is the end product of purine nucleotide metabolism in the human body.
Hyperuricemia is an abnormally high level of UA in the blood and may result in arthritis and …

Since the 2018 ISPAD guidelines on this topic, follow‐up of large cohorts from around the
globe have continued informing the current incidence and prevalence of co‐morbidities and …

The molecular mechanisms of sodium-glucose cotransporter-2 (SGLT2) inhibitors (SGLT2i)
remain incompletely understood. Single-cell RNA sequencing and morphometric data were …

The dramatic increase in overweight and obesity among children and adolescents has
become a major public health problem. Obesity in children and young adults is associated …

SUMMARY OBJECTIVE: Non-alcoholic fatty liver disease, which is characterized by lipid
being deposited into hepatocytes, affects nearly one in three adults globally. Inflammatory …

The incidence and prevalence of youth-onset type 2 diabetes mellitus (T2DM) and its
complications are increasing worldwide. Youth-onset T2DM has been reported in all racial …

Cardiovascular diseases (CVDs) are the prevalent cause of mortality around the world.
Activation of inflammasome contributes to the pathological progression of cardiovascular …

It is well established that the maternal diet during the periconceptional period affects the
progeny's health. A growing body of evidence suggests that the paternal diet also influences …

Hyperuricemia has long been recognized to be associated with increased cardiovascular
risk, including risk of developing hypertension. Epidemiological findings suggest that the link …

Importance Diabetic kidney disease is among the most important causes of end-stage
kidney disease worldwide. Risk factors for diabetic kidney disease remain incompletely …