[HTML][HTML] Persistent coxsackievirus B infection and pathogenesis of type 1 diabetes mellitus
Enteroviruses are believed to trigger or accelerate islet autoimmunity in genetically
susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and …
susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and …
[HTML][HTML] Pathogenesis of type 1 diabetes: established facts and new insights
A Zajec, K Trebušak Podkrajšek, T Tesovnik, R Šket… - Genes, 2022 - mdpi.com
Type 1 diabetes (T1D) is an autoimmune disease characterized by the T-cell-mediated
destruction of insulin-producing β-cells in pancreatic islets. It generally occurs in genetically …
destruction of insulin-producing β-cells in pancreatic islets. It generally occurs in genetically …
[HTML][HTML] 100 YEARS OF INSULIN: Pancreas pathology in type 1 diabetes: an evolving story
SJ Richardson, A Pugliese - Journal of endocrinology, 2022 - joe.bioscientifica.com
We review the current knowledge of pancreas pathology in type 1 diabetes. During the last
two decades, dedicated efforts toward the recovery of pancreas from deceased patients with …
two decades, dedicated efforts toward the recovery of pancreas from deceased patients with …
[HTML][HTML] Persistent enterovirus infection: little deletions, long infections
NM Chapman - Vaccines, 2022 - mdpi.com
Enteroviruses have now been shown to persist in cell cultures and in vivo by a novel
mechanism involving the deletion of varying amounts of the 5′ terminal genomic region …
mechanism involving the deletion of varying amounts of the 5′ terminal genomic region …
[HTML][HTML] Antiviral activity of some benzo [g] quinazolines against coxsackievirus B4: Biological screening and docking study
HA Abuelizz, AH Bakheit, M Marzouk… - Pharmacological …, 2023 - Springer
Abstract Background Serotype coxsackievirus B (CVB) infection has been linked to viral
myocarditis, dilated cardiomyopathy, meningitis, and pancreatitis in children and young …
myocarditis, dilated cardiomyopathy, meningitis, and pancreatitis in children and young …
[HTML][HTML] Viruses and endocrine diseases
Viral infections have been frequently associated with physiological and pathological
changes in the endocrine system for many years. The numerous early and late endocrine …
changes in the endocrine system for many years. The numerous early and late endocrine …
[HTML][HTML] The possible role of viral infections in acute pancreatitis: a review of literature
B Sarshari, R Zareh-Khoshchehreh… - … and Hepatology From …, 2023 - ncbi.nlm.nih.gov
Acute pancreatitis, a potentially fatal disease, with symptoms including nausea and/or
vomiting, indigestion, and abdominal pain, is known to range from a mild self-limiting state …
vomiting, indigestion, and abdominal pain, is known to range from a mild self-limiting state …
Vemurafenib Inhibits Acute and Chronic Enterovirus Infection by Affecting Cellular Kinase Phosphatidylinositol 4-Kinase Type IIIβ
M Laajala, M Zwaagstra, M Martikainen… - Microbiology …, 2023 - Am Soc Microbiol
Enteroviruses are one of the most abundant viruses causing mild to serious acute infections
in humans and also contributing to chronic diseases like type 1 diabetes. Presently, there …
in humans and also contributing to chronic diseases like type 1 diabetes. Presently, there …
[HTML][HTML] Replication Activities of Major 5′ Terminally Deleted Group-B Coxsackievirus RNA Forms Decrease PCSK2 mRNA Expression Impairing Insulin Maturation …
D Callon, A Guedra, AL Lebreil, L Heng, N Bouland… - Viruses, 2022 - mdpi.com
Emergence of 5′ terminally deleted coxsackievirus-B RNA forms (CVB-TD) have been
associated with the development of human diseases. These CVB-TD RNA forms have been …
associated with the development of human diseases. These CVB-TD RNA forms have been …
[HTML][HTML] Immunological and virological triggers of type 1 diabetes: insights and implications
JRN Lemos, K Hirani, M von Herrath - Frontiers in Immunology, 2024 - frontiersin.org
Type 1 diabetes (T1D) is caused by an autoimmune process which culminates in the
destruction of insulin-producing beta cells in the pancreas. It is widely believed that a …
destruction of insulin-producing beta cells in the pancreas. It is widely believed that a …