Putting p53 in context
ER Kastenhuber, SW Lowe - Cell, 2017 - cell.com
TP53 is the most frequently mutated gene in human cancer. Functionally, p53 is activated by
a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative …
a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative …
[HTML][HTML] Stem cells and the differentiation hierarchy in mammary gland development
NY Fu, E Nolan, GJ Lindeman… - Physiological …, 2020 - journals.physiology.org
The mammary gland is a highly dynamic organ that undergoes profound changes within its
epithelium during puberty and the reproductive cycle. These changes are fueled by …
epithelium during puberty and the reproductive cycle. These changes are fueled by …
Cellular and molecular mechanisms of plasticity in cancer
Cancer cells are plastic–they can assume a wide range of distinct phenotypes. Plasticity is
integral to cancer initiation and progression, as well as to the emergence and maintenance …
integral to cancer initiation and progression, as well as to the emergence and maintenance …
CDK12 promotes tumorigenesis but induces vulnerability to therapies inhibiting folate one-carbon metabolism in breast cancer
MG Filippone, D Gaglio, R Bonfanti, FA Tucci… - Nature …, 2022 - nature.com
Abstract Cyclin-dependent kinase 12 (CDK12) overexpression is implicated in breast
cancer, but whether it has a primary or only a cooperative tumorigenic role is unclear. Here …
cancer, but whether it has a primary or only a cooperative tumorigenic role is unclear. Here …
Inadequate DNA damage repair promotes mammary transdifferentiation, leading to BRCA1 breast cancer
Loss of BRCA1 p220 function often results in basal-like breast cancer (BLBC), but the
underlying disease mechanism is largely opaque. In mammary epithelial cells (MECs) …
underlying disease mechanism is largely opaque. In mammary epithelial cells (MECs) …
Single-cell RNA sequencing: technological progress and biomedical application in cancer research
X Chang, Y Zheng, K Xu - Molecular Biotechnology, 2024 - Springer
Single-cell RNA-seq (scRNA-seq) is a revolutionary technology that allows for the genomic
investigation of individual cells in a population, allowing for the discovery of unusual cells …
investigation of individual cells in a population, allowing for the discovery of unusual cells …
p53 loss in breast cancer leads to Myc activation, increased cell plasticity, and expression of a mitotic signature with prognostic value
Loss of p53 function is invariably associated with cancer. Its role in tumor growth was
recently linked to its effects on cancer stem cells (CSCs), although the underlying molecular …
recently linked to its effects on cancer stem cells (CSCs), although the underlying molecular …
[HTML][HTML] MiR-31-5p promotes the cell growth, migration and invasion of colorectal cancer cells by targeting NUMB
H Peng, L Wang, Q Su, K Yi, J Du, Z Wang - Biomedicine & …, 2019 - Elsevier
The aim of this study was to investigate the role and specific molecular mechanism of miR-
31-5 in colorectal cancer. The relative expression of miR-31-5p and NUMB in colorectal …
31-5 in colorectal cancer. The relative expression of miR-31-5p and NUMB in colorectal …
[HTML][HTML] p53 regulates progenitor cell quiescence and differentiation in the airway
Mechanisms that regulate progenitor cell quiescence and differentiation in slowly replacing
tissues are not fully understood. Here, we demonstrate that the tumor suppressor p53 …
tissues are not fully understood. Here, we demonstrate that the tumor suppressor p53 …
p140Cap inhibits β-Catenin in the breast cancer stem cell compartment instructing a protective anti-tumor immune response
V Salemme, M Vedelago, A Sarcinella… - Nature …, 2023 - nature.com
The p140Cap adaptor protein is a tumor suppressor in breast cancer associated with a
favorable prognosis. Here we highlight a function of p140Cap in orchestrating local and …
favorable prognosis. Here we highlight a function of p140Cap in orchestrating local and …