Gram-positive organisms, including the pathogens Staphylococcus aureus, Streptococcus
pneumoniae, and Enterococcus faecalis, have dynamic cell envelopes that mediate …

The peptidoglycan biosynthetic pathway is a critical process in the bacterial cell and is
exploited as a target for the design of antibiotics. This pathway culminates in the production …

Staphylococcus aureus is an important human and livestock pathogen that is well-protected
against environmental insults by a thick cell wall. Accordingly, the wall is a major target of …

Peptidoglycan (PG) is an essential component in the cell wall of nearly all bacteria, forming
a continuous, mesh-like structure, called the sacculus, around the cytoplasmic membrane to …

Peptidoglycan (PG) is an essential macromolecular sacculus surrounding most bacteria. It is
assembled by the glycosyltransferase (GT) and transpeptidase (TP) activities of …

The development of antibiotic resistance in Staphylococcus aureus, particularly in methicillin-
resistant S. aureus (MRSA), has become a significant health concern worldwide. The …

Bacteria utilize specialized multi-protein machineries to synthesize the essential
peptidoglycan (PG) cell wall during growth and division. The divisome controls septal PG …

Methicillin-resistant Staphylococcus aureus (MRSA) strains show strain-to-strain variation in
resistance level, in genetic background, and also in the structure of the chromosomal …

Bacterial cell wall synthesis is the target for some of our most powerful antibiotics and has
thus been the subject of intense research focus for more than 50 years. Surprisingly, we still …

Many important cellular processes are performed by molecular machines, composed of
multiple proteins that physically interact to execute biological functions. An example is the …