Chemokine receptor CCR6 is expressed on various cells such as B cells, immature dendritic
cells, innate lymphoid cells (ILCs), regulatory CD4 T cells, and Th17 cells. CCL20 is the only …

Uveitis is a group of diseases characterized by intraocular inflammation, of which some are
driven by autoinflammatory or autoimmune responses, such as Vogt-Koyanagi-Harada …

Several risk factors for Crohn's disease have been identified in recent genome-wide
association studies. To advance gene discovery further, we combined data from three …

Rationale: Pulmonary sarcoidosis is classically defined by T-helper (Th) cell type 1
inflammation (eg, IFN-γ production by CD4+ effector T cells). Recently, IL-17A–secreting …

Background and aims Sarcoidosis is characterised by a compartmentalisation of CD4+ T
helper 1 (Th1) lymphocytes and activated macrophages in involved organs, including the …

Sarcoidosis is a granulomatous disorder of unknown cause, affecting multiple organs, but
mainly the lungs. The exact order of immunological events remains obscure. Reviewing …

Sarcoidosis is an enigmatic multisystem disease characterized by the development and
accumulation of granulomas: a compact collection of macrophages that have differentiated …

Childhood sarcoidosis is a rare multisystemic granulomatous disorder of unknown etiology.
In the pediatric series reported from the southeastern United States, sarcoidosis had a …

The lung-draining mediastinal lymph nodes (MLNs) are currently widely used to diagnose
sarcoidosis. We previously reported that T-helper (Th) 17.1 cells are responsible for the …

Background Sarcoidosis is a multisystem granulomatous disease of unknown origin with a
variable and often unpredictable course and pattern of organ involvement. In this study we …