An atlas of alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability
Genome-wide association studies have identified thousands of noncoding variants
associated with human traits and diseases. However, the functional interpretation of these …
associated with human traits and diseases. However, the functional interpretation of these …
QTQTN motif upstream of the furin-cleavage site plays a key role in SARS-CoV-2 infection and pathogenesis
The furin cleavage site (FCS), an unusual feature in the SARS-CoV-2 spike protein, has
been spotlighted as a factor key to facilitating infection and pathogenesis by increasing …
been spotlighted as a factor key to facilitating infection and pathogenesis by increasing …
Alternative polyadenylation alters protein dosage by switching between intronic and 3′ UTR sites
Alternative polyadenylation (APA) creates distinct transcripts from the same gene by
cleaving the pre-mRNA at poly (A) sites that can lie within the 3′ untranslated region (3 …
cleaving the pre-mRNA at poly (A) sites that can lie within the 3′ untranslated region (3 …
Generation and characterization of human Fetal membrane and Decidual cell lines for reproductive biology experiments
Human fetal membrane and maternal decidua parietalis form one of the major feto-maternal
interfaces during pregnancy. Studies on this feto-maternal interface is limited as several …
interfaces during pregnancy. Studies on this feto-maternal interface is limited as several …
Tau modulates mRNA transcription, alternative polyadenylation profiles of hnRNPs, chromatin remodeling and spliceosome complexes
M Montalbano, E Jaworski, S Garcia… - Frontiers in Molecular …, 2021 - frontiersin.org
Tau protein is a known contributor in several neurodegenerative diseases, including
Alzheimer's disease (AD) and frontotemporal dementia (FTD). It is well-established that tau …
Alzheimer's disease (AD) and frontotemporal dementia (FTD). It is well-established that tau …
Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome
Pumilio paralogs, PUM1 and PUM2, are sequence-specific RNA-binding proteins that are
essential for vertebrate development and neurological functions. PUM1&2 negatively …
essential for vertebrate development and neurological functions. PUM1&2 negatively …
Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation
We previously showed that NUDT21-spanning copy-number variations (CNVs) are
associated with intellectual disability (Gennarino et al., 2015). However, the patients' CNVs …
associated with intellectual disability (Gennarino et al., 2015). However, the patients' CNVs …
Sex-chromosome mechanisms in cardiac development and disease
Many human diseases, including cardiovascular disease, show differences between men
and women in pathology and treatment outcomes. In the case of cardiac disease, sex …
and women in pathology and treatment outcomes. In the case of cardiac disease, sex …
SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A
AM Scarborough, JN Flaherty, OV Hunter, K Liu… - Elife, 2021 - elifesciences.org
S-adenosylmethionine (SAM) is the methyl donor for nearly all cellular methylation events.
Cells regulate intracellular SAM levels through intron detention of MAT2A, the only SAM …
Cells regulate intracellular SAM levels through intron detention of MAT2A, the only SAM …
PolyA-miner: Accurate assessment of differential alternative poly-adenylation from 3′ Seq data using vector projections and non-negative matrix factorization
Almost 70% of human genes undergo alternative polyadenylation (APA) and generate
mRNA transcripts with varying lengths, typically of the 3′ untranslated regions (UTR). APA …
mRNA transcripts with varying lengths, typically of the 3′ untranslated regions (UTR). APA …